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Abevmy · 4.5 · The safety and efficacy of concomitant administration of radiotherapy and bevacizumab has not been established
Eintrag öffnenAbevmy · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenAbevmy · 4.8 · 11 different chemotherapy regimens in multiple indications, by MedDRA system organ class.
Eintrag öffnenAbevmy · 4.8 · 12 Table 1: Adverse reactions by frequency System organ Very common Common Rare Very rare Not known class Infe
Eintrag öffnenAbevmy · 4.8 · 14 Table 2: Severe adverse reactions by frequency
Eintrag öffnenAbevmy · 4.8 · 16 Fatal outcome was reported in approximately a third of serious cases of gastrointestinal perforations, whic
Eintrag öffnenAbevmy · 4.8 · 17 Hypertension (see section 4.4)
Eintrag öffnenAbevmy · 4.8 · 18 reactions ranged from 0.4% to 6.9% in bevacizumab treated patients, compared with up to 4.5% of patients in
Eintrag öffnenAbevmy · 4.8 · 19 Arterial thromboembolism An increased incidence of arterial thromboembolic reactions was observed in patien
Eintrag öffnenAbevmy · 4.8 · 20 ventricular function following appropriate medical therapy.
Eintrag öffnenAbevmy · 4.8 · 21 Other special populations
Eintrag öffnenAbevmy · 4.8 · 22 Table 3: Adverse reactions reported in post-marketing setting MedDRA system organ Reactions (frequency*) cl
Eintrag öffnenAbevmy · 4.8 · Adverse reactions are added to the appropriate frequency category in the tables below according to the highest
Eintrag öffnenAbevmy · 4.8 · Anaphylactic shock (rare) (see also section 4.4) Nervous system disorders Hypertensive encephalopathy (very ra
Eintrag öffnenAbevmy · 4.8 · Bevacizumab has been associated with serious cases of gastrointestinal perforation.
Eintrag öffnenAbevmy · 4.8 · Bevacizumab use has been associated with serious cases of fistulae including reactions resulting in death.
Eintrag öffnenAbevmy · 4.8 · Description of selected serious adverse reactions
Eintrag öffnenAbevmy · 4.8 · Gastrointestinal (GI) perforations and fistulae (see section 4.4)
Eintrag öffnenAbevmy · 4.8 · Gastrointestinal perforations have been reported in clinical trials with an incidence of less than 1% in patie
Eintrag öffnenAbevmy · 4.8 · Grade 3-5 (NCI-CTCAE v.3) venous thromboembolic reactions have been reported in up to 7.8% of patients treated
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