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Ivemend · 4.5 · Diltiazem Interaction studies with fosaprepitant 150 mg and diltiazem have not been conducted; however, the fo
Eintrag öffnenIvemend · 4.5 · Effect of fosaprepitant on the pharmacokinetics of other active substances CYP3A4 inhibition As a weak inhibit
Eintrag öffnenIvemend · 4.5 · Fosaprepitant 150 mg, given as a single dose, is a weak inhibitor of CYP3A4. Fosaprepitant does not seem to in
Eintrag öffnenIvemend · 4.5 · Hormonal contraceptives The efficacy of hormonal contraceptives may be reduced during and for 28 days after ad
Eintrag öffnenIvemend · 4.5 · Induction The fosaprepitant 150 mg single dose did not induce CYP3A4 on Days 1 and 4 in the midazolam interact
Eintrag öffnenIvemend · 4.5 · Interactions with other medicinal products following administration of intravenous fosaprepitant are likely to
Eintrag öffnenIvemend · 4.5 · Midazolam Fosaprepitant 150 mg administered as a single intravenous dose on Day 1 increased the AUC0-∞ of mida
Eintrag öffnenIvemend · 4.5 · Paediatric population Interaction studies have only been performed in adults.
Eintrag öffnenIvemend · 4.5 · The following information was derived from studies conducted with oral aprepitant and studies conducted with i
Eintrag öffnenIvemend · 4.5 · The potential effects of increased plasma concentrations of midazolam or other benzodiazepines metabolised via
Eintrag öffnenIvemend · 4.5 · Warfarin In patients on chronic warfarin therapy, the prothrombin time (INR) should be monitored closely durin
Eintrag öffnenIvemend · 4.5 · When administered intravenously fosaprepitant is rapidly converted to aprepitant.
Eintrag öffnenIvemend · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenIvemend · 4.8 Undesirable effects · 1
Eintrag öffnenIvemend · 4.8 · 10 System organ class Adverse reaction Frequency Cardiac disorders palpitations uncommon bradycardia, cardiova
Eintrag öffnenIvemend · 4.8 · 11 patients receiving MEC, safety was evaluated for 504 patients receiving a single dose of IVEMEND 150 mg com
Eintrag öffnenIvemend · 4.8 · Blood and lymphatic system febrile neutropenia, anaemia uncommon disorders
Eintrag öffnenIvemend · 4.8 · Description of selected adverse reactions The adverse reactions profiles in the Multiple-Cycle extension of HE
Eintrag öffnenIvemend · 4.8 · Fosaprepitant In an active-controlled clinical study in adult patients receiving HEC, safety was evaluated for
Eintrag öffnenIvemend · 4.8 · Frequencies are defined as: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare
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