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Orfadin · 4.3 · Mothers receiving nitisinone must not breast-feed (see sections 4.6 and 5.3).
Eintrag öffnenOrfadin · 4.3 · Mothers receiving nitisinone must not breast-feed (see sections 4.6 and 5.3).
Eintrag öffnenOrfadin · 4.5 · Based on data from a clinical interaction study with 80 mg nitisinone at steady-state, nitisinone is a moderat
Eintrag öffnenOrfadin · 4.5 · Based on data from a clinical interaction study with 80 mg nitisinone at steady-state, nitisinone is a moderat
Eintrag öffnenOrfadin · 4.5 · Food does not influence the bioavailability of nitisinone oral suspension, but intake together with food decre
Eintrag öffnenOrfadin · 4.5 · Nitisinone is metabolised in vitro by CYP 3A4 and dose-adjustment may therefore be needed when nitisinone is c
Eintrag öffnenOrfadin · 4.5 · Nitisinone is metabolised in vitro by CYP 3A4 and dose-adjustment may therefore be needed when nitisinone is c
Eintrag öffnenOrfadin · 4.5 · No formal food interactions studies have been performed with Orfadin hard capsules. However, nitisinone has be
Eintrag öffnenOrfadin · 4.8 · Description of selected adverse reactions Nitisinone treatment leads to elevated tyrosine levels. Elevated lev
Eintrag öffnenOrfadin · 4.8 · Description of selected adverse reactions Nitisinone treatment leads to elevated tyrosine levels. Elevated lev
Eintrag öffnenOrfadin · 4.8 · Paediatric population The safety profile in HT-1 is mainly based on the paediatric population since nitisinone
Eintrag öffnenOrfadin · 4.8 · Paediatric population The safety profile in HT-1 is mainly based on the paediatric population since nitisinone
Eintrag öffnenOrfadin · 4.8 · Summary of the safety profile By its mode of action, nitisinone increases tyrosine levels in all nitisinone-tr
Eintrag öffnenOrfadin · 4.8 · Summary of the safety profile By its mode of action, nitisinone increases tyrosine levels in all nitisinone-tr
Eintrag öffnenOrgovyx · 4.5 · Antiarrhythmics amiodarone, 6 dronedarone, propafenone, quinidine.
Eintrag öffnenOtezla · 4.8 · 8 from weight loss. None of the patients discontinued the study due to adverse reaction of weight decreased.
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