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Cotellic · 4.5 · CYP3A and CYP2D6 substrates
Eintrag öffnenCotellic · 4.5 · Cobimetinib is a substrate of P-glycoprotein (P-gp). Concomitant administration of P-gp inhibitors such as cic
Eintrag öffnenCotellic · 4.5 · In vitro studies show that cobimetinib is not a substrate of the liver uptake transporters OATP1B1, OATP1B3 an
Eintrag öffnenCotellic · 4.5 · In vitro, cobimetinib is a potential inducer of CYP1A2 and may therefore reduce the exposure of substrates of
Eintrag öffnenCresemba · 4.5 · (CYP3A4/5 induction) Anticoagulants Dabigatran etexilate Not studied. No isavuconazole dose (P-gp substrate) D
Eintrag öffnenCresemba · 4.5 · (UGT inhibition) Prednisone Prednisolone (active metabolite): Co-administration should be (CYP3A4 substrate) A
Eintrag öffnenCresemba · 4.5 · (UGT inhibition) Prednisone Prednisolone (active metabolite): Co-administration should be (CYP3A4 substrate) A
Eintrag öffnenCresemba · 4.5 · 11 Digoxin Digoxin: No isavuconazole dose (P-gp substrate) AUCinf: ↑ 25% adjustment necessary. Cmax: ↑ 33% Dig
Eintrag öffnenCresemba · 4.5 · 34 Antigout agent Colchicine Not studied. No isavuconazole dose (P-gp substrate) Colchicine concentrations may
Eintrag öffnenCresemba · 4.5 · Isavuconazole is a substrate of CYP3A4 and CYP3A5 (see section 5.2). Co-administration of medicinal products w
Eintrag öffnenCresemba · 4.5 · Isavuconazole is a substrate of CYP3A4 and CYP3A5 (see section 5.2). Co-administration of medicinal products w
Eintrag öffnenCresemba · 4.5 · Isavuconazole is an inhibitor in vitro of BCRP, and plasma concentrations of substrates of BCRP may therefore
Eintrag öffnenCresemba · 4.5 · Isavuconazole is an inhibitor in vitro of BCRP, and plasma concentrations of substrates of BCRP may therefore
Eintrag öffnenCresemba · 4.5 · Uridine diphosphate-glucuronosyltransferases (UGT) substrates
Eintrag öffnenCresemba · 4.5 · Uridine diphosphate-glucuronosyltransferases (UGT) substrates
Eintrag öffnenCrk-assoziiertes-Substrat-Protein
Eintrag öffnenCymbalta · 4.5 · 7 substrate, were not significantly affected by co-administration with duloxetine (60 mg twice daily).
Eintrag öffnenDarunavir Viatris (previously Darunavir Mylan) · 4.5 · (Rifabutin is an inducer and substrate of CYP3A.) An increase of systemic exposure to darunavir was observed w
Eintrag öffnenDarunavir Viatris (previously Darunavir Mylan) · 4.5 · Ritonavir inhibits the transporters P-glycoprotein, OATP1B1 and OATP1B3, and co-administration with substrates
Eintrag öffnenDarunavir Viatris (previously Darunavir Mylan) · 4.5 · Ritonavir inhibits the transporters P-glycoprotein, OATP1B1 and OATP1B3, and co-administration with substrates
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