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Alecensa · 4.5 · 6 combined exposure of alectinib and M4 was minor, reducing Cmax and AUCinf by 4 % and 18 %, respectively. Bas
Eintrag öffnenCibinqo · 4.5 · Co-administration of abrocitinib 200 mg once daily with caffeine 100 mg single dose increased the AUCinf of ca
Eintrag öffnenCresemba · 4.5 · (CYP3A4/5 induction) Indinavir Indinavir:b) No isavuconazole dose (CYP3A4/5 strong inhibitor AUCinf: ↓ 36% adj
Eintrag öffnenCresemba · 4.5 · (CYP3A4/5 induction) Indinavir Indinavir:b) No isavuconazole dose (CYP3A4/5 strong inhibitor AUCinf: ↓ 36% adj
Eintrag öffnenCresemba · 4.5 · 11 Digoxin Digoxin: No isavuconazole dose (P-gp substrate) AUCinf: ↑ 25% adjustment necessary. Cmax: ↑ 33% Dig
Eintrag öffnenCresemba · 4.5 · Tacrolimus: AUCinf: ↑ 125% Cmax: ↑ 42%
Eintrag öffnenIbrance · 4.5 · 7 by 41%, but had limited impact on AUCinf (13% decrease) compared with a single dose of 125 mg IBRANCE admini
Eintrag öffnenIqirvo · 4.5 · The Cmax and AUCinf of atorvastatin decreased by 28% and 11% respectively following concomitant use of a singl
Eintrag öffnenIqirvo · 4.5 · The Cmax and AUCinf of the active metabolite of simvastatin, simavastatin β-hydroxyacid, decreased by 26% and
Eintrag öffnenLitfulo · 4.5 · Multiple doses of 200 mg once daily ritlecitinib increased the AUCinf and Cmax of caffeine, a CYP1A2 substrate
Eintrag öffnenLitfulo · 4.5 · Multiple doses of 200 mg once daily ritlecitinib increased the AUCinf and Cmax of midazolam a CYP3A4 substrate
Eintrag öffnenLitfulo · 4.5 · The coadministration of a single 400 mg dose of ritlecitinib increased the AUCinf of sumatriptan (an organic c
Eintrag öffnenLorviqua · 4.5 · Lorlatinib 100 mg once daily for 15 days decreased AUCinf and Cmax of a single oral 100 mg dose of bupropion (
Eintrag öffnenLorviqua · 4.5 · Lorlatinib 100 mg once daily for 15 days decreased AUCinf and Cmax of a single oral 500 mg dose of acetaminoph
Eintrag öffnenLorviqua · 4.5 · Lorlatinib 100 mg once daily for 15 days decreased AUCinf and Cmax of a single oral 500 mg dose of tolbutamide
Eintrag öffnenLorviqua · 4.5 · Lorlatinib 100 mg once daily for 15 days decreased AUCinf and Cmax of a single oral dose of 60 mg fexofenadine
Eintrag öffnenRubraca · 4.5 · 6 CYP3A substrates Rucaparib increased midazolam Cmax by 1.13 fold (90% CI: 0.95 to 1.36) and AUCinf by 1.38 f
Eintrag öffnenRubraca · 4.5 · BCRP substrates Rucaparib increased rosuvastatin Cmax by 1.29 fold (90% CI: 1.07 to 1.55) and AUCinf by 1.35 f
Eintrag öffnenRubraca · 4.5 · CYP1A2 substrates Rucaparib showed no effect on Cmax of caffeine while moderately increasing AUCinf of caffein
Eintrag öffnenRubraca · 4.5 · CYP2C19 substrates Rucaparib increased omeprazole Cmax by 1.09 fold (90% CI: 0.93 to 1.27) and AUCinf by 1.55
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