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Abirateronacetat
Eintrag öffnenAbiraterone Mylan
Eintrag öffnenAbiraterone Mylan · 4.1 Therapeutic indications · 1
Eintrag öffnenAbiraterone Mylan · 4.3 Contraindications · 1
Eintrag öffnenAbiraterone Mylan · 4.3 · • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. • Women who are
Eintrag öffnenAbiraterone Mylan · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenAbiraterone Mylan · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenAbiraterone Mylan · 4.5 · Caution is advised when administering with medicinal products activated by or metabolised by CYP2D6, particula
Eintrag öffnenAbiraterone Mylan · 4.5 · Effect of food on abiraterone Administration with food significantly increases the absorption of abiraterone.
Eintrag öffnenAbiraterone Mylan · 4.5 · In a CYP2C8 drug-drug interaction study in healthy subjects, the AUC of pioglitazone was increased by 46% and
Eintrag öffnenAbiraterone Mylan · 4.5 · In a separate clinical pharmacokinetic interaction study of healthy subjects, co-administration of ketoconazol
Eintrag öffnenAbiraterone Mylan · 4.5 · In vitro, the major metabolites abiraterone sulphate and N-oxide abiraterone sulphate were shown to inhibit th
Eintrag öffnenAbiraterone Mylan · 4.5 · Interactions with other medicinal products Potential for other medicinal products to affect abiraterone exposu
Eintrag öffnenAbiraterone Mylan · 4.5 · Potential to affect exposures to other medicinal products Abiraterone is an inhibitor of the hepatic drug-meta
Eintrag öffnenAbiraterone Mylan · 4.5 · Strong inducers of CYP3A4 (e.g., phenytoin, carbamazepine, rifampicin, rifabutin, rifapentine, phenobarbital,
Eintrag öffnenAbiraterone Mylan · 4.5 · Use with products known to prolong QT interval Since androgen deprivation treatment may prolong the QT interva
Eintrag öffnenAbiraterone Mylan · 4.5 · Use with spironolactone Spironolactone binds to the androgen receptor and may increase prostate specific antig
Eintrag öffnenAbiraterone Mylan · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenAbiraterone Mylan · 4.8 Undesirable effects · 1
Eintrag öffnenAbiraterone Mylan · 4.8 · 7 reactions that were observed in ≥ 10 % of patients were peripheral oedema, hypokalaemia, hypertension, urina
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