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Afinitor
Eintrag öffnenAfinitor · 4.1 Therapeutic indications · 1
Eintrag öffnenAfinitor · 4.3 Contraindications · 1
Eintrag öffnenAfinitor · 4.3 · Hypersensitivity to the active substance, to other rapamycin derivatives or to any of the excipients listed in
Eintrag öffnenAfinitor · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenAfinitor · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenAfinitor · 4.5 · 10 Afinitor (see section 4.4). Examples of live vaccines are: intranasal influenza, measles, mumps, rubella, o
Eintrag öffnenAfinitor · 4.5 · 8 Table 2 Effects of other active substances on everolimus
Eintrag öffnenAfinitor · 4.5 · 9 Potent and moderate CYP3A4 inducers Rifampicin AUC ↓63% Avoid the use of concomitant (range 0-80%) potent CY
Eintrag öffnenAfinitor · 4.5 · Active substance by Interaction – Change in Recommendations concerning interaction Everolimus AUC/Cmax co-admi
Eintrag öffnenAfinitor · 4.5 · Agents whose plasma concentration may be altered by everolimus
Eintrag öffnenAfinitor · 4.5 · Based on in vitro results, the systemic concentrations obtained after oral daily doses of 10 mg make inhibitio
Eintrag öffnenAfinitor · 4.5 · CYP3A4 and PgP inducers decreasing everolimus concentrations
Eintrag öffnenAfinitor · 4.5 · CYP3A4 and PgP inhibitors increasing everolimus concentrations
Eintrag öffnenAfinitor · 4.5 · Co-administration of everolimus and depot octreotide increased octreotide Cmin with a geometric mean ratio (ev
Eintrag öffnenAfinitor · 4.5 · Co-administration of everolimus and exemestane increased exemestane Cmin and C2h by 45% and 64%, respectively.
Eintrag öffnenAfinitor · 4.5 · Concomitant use of angiotensin-converting enzyme (ACE) inhibitors
Eintrag öffnenAfinitor · 4.5 · Everolimus is a substrate of CYP3A4, and also a substrate and moderate inhibitor of PgP. Therefore, absorption
Eintrag öffnenAfinitor · 4.5 · Known and theoretical interactions with selected inhibitors and inducers of CYP3A4 and PgP are listed in Table
Eintrag öffnenAfinitor · 4.5 · Patients taking concomitant ACE inhibitor (e.g. ramipril) therapy may be at increased risk for angioedema (see
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