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Akeega
Eintrag öffnenAkeega · 4.1 Therapeutic indications · 1
Eintrag öffnenAkeega · 4.3 Contraindications · 1
Eintrag öffnenAkeega · 4.3 · Akeega plus prednisone or prednisolone is contraindicated in combination with Ra-223 treatment.
Eintrag öffnenAkeega · 4.3 · Hypersensitivity to the active substances or to any of the excipients listed in section 6.1.
Eintrag öffnenAkeega · 4.3 · Severe hepatic impairment [Child-Pugh Class C (see sections 4.2, 4.4 and 5.2)].
Eintrag öffnenAkeega · 4.3 · Women who are or may become pregnant (see section 4.6).
Eintrag öffnenAkeega · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenAkeega · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenAkeega · 4.5 · 9 wort [Hypericum perforatum]) during treatment with Akeega should be avoided unless there is no therapeutic a
Eintrag öffnenAkeega · 4.5 · CYP2C8 substrates Abiraterone is an inhibitor of CYP2C8. In a clinical study in healthy subjects, the AUC of p
Eintrag öffnenAkeega · 4.5 · Effects of niraparib or abiraterone acetate on other medicinal products CYP2D6 substrates Abiraterone is an in
Eintrag öffnenAkeega · 4.5 · Effects of other medicinal products on niraparib or abiraterone acetate CYP3A4 inducers and inhibitors Abirate
Eintrag öffnenAkeega · 4.5 · In a separate clinical study in healthy subjects, co-administration of ketoconazole, a strong inhibitor of CYP
Eintrag öffnenAkeega · 4.5 · Pharmacodynamic interactions Akeega with vaccines or immunosuppressant agents has not been studied. The data o
Eintrag öffnenAkeega · 4.5 · Pharmacokinetic interactions No clinical study evaluating drug interactions has been performed using Akeega. I
Eintrag öffnenAkeega · 4.5 · Use with products known to prolong QT interval Since androgen deprivation treatment may prolong the QT interva
Eintrag öffnenAkeega · 4.5 · Use with spironolactone Spironolactone binds to the androgen receptor and may increase prostate specific antig
Eintrag öffnenAkeega · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenAkeega · 4.8 Undesirable effects · 1
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