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Aubagio
Eintrag öffnenAubagio · 4.1 Therapeutic indications · 1
Eintrag öffnenAubagio · 4.3 Contraindications · 1
Eintrag öffnenAubagio · 4.3 · 3 Patients with severe active infection until resolution (see section 4.4).
Eintrag öffnenAubagio · 4.3 · Breast-feeding women (see section 4.6).
Eintrag öffnenAubagio · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenAubagio · 4.3 · Patients with severe hepatic impairment (Child-Pugh class C).
Eintrag öffnenAubagio · 4.3 · Patients with severe hypoproteinaemia, e.g. in nephrotic syndrome.
Eintrag öffnenAubagio · 4.3 · Patients with severe immunodeficiency states, e.g. acquired immunodeficiency syndrome (AIDS).
Eintrag öffnenAubagio · 4.3 · Patients with severe renal impairment undergoing dialysis, because insufficient clinical experience is availab
Eintrag öffnenAubagio · 4.3 · Patients with significantly impaired bone marrow function or significant anaemia, leukopenia, neutropenia or t
Eintrag öffnenAubagio · 4.3 · Pregnant women, or women of childbearing potential who are not using reliable contraception during treatment w
Eintrag öffnenAubagio · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenAubagio · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenAubagio · 4.5 · 7 The primary biotransformation pathway for teriflunomide is hydrolysis, with oxidation being a minor pathway.
Eintrag öffnenAubagio · 4.5 · 8 There was an increase in mean rosuvastatin Cmax and AUC (2.65- and 2.51-fold, respectively), following repea
Eintrag öffnenAubagio · 4.5 · Cholestyramine or activated charcoal It is recommended that patients receiving teriflunomide are not treated w
Eintrag öffnenAubagio · 4.5 · Effect of teriflunomide on BCRP and /or organic anion transporting polypeptide B1 and B3 (OATP1B1/B3) substrat
Eintrag öffnenAubagio · 4.5 · Effect of teriflunomide on CYP1A2 substrate: caffeine Repeated doses of teriflunomide decreased mean Cmax and
Eintrag öffnenAubagio · 4.5 · Effect of teriflunomide on CYP2C8 substrate: repaglinide There was an increase in mean repaglinide Cmax and AU
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