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Bosulif
Eintrag öffnenBosulif · 4.1 Therapeutic indications · 1
Eintrag öffnenBosulif · 4.3 Contraindications · 1
Eintrag öffnenBosulif · 4.3 · Hepatic impairment (see sections 5.1 and 5.2).
Eintrag öffnenBosulif · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenBosulif · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenBosulif · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenBosulif · 4.5 · 10 increased bosutinib Cmax by 1.5-fold, and bosutinib AUC in plasma by 2.0-fold, as compared with administrat
Eintrag öffnenBosulif · 4.5 · An in vitro study indicates that drug-drug interactions are unlikely to occur at therapeutic doses as a result
Eintrag öffnenBosulif · 4.5 · Anti-arrhythmic medicinal products and other substances that may prolong QT Bosutinib should be used with caut
Eintrag öffnenBosulif · 4.5 · Based on the large reduction in bosutinib exposure that occurred when bosutinib was co-administered with rifam
Eintrag öffnenBosulif · 4.5 · CYP3A inducers The concomitant use of bosutinib with strong CYP3A inducers (including, but not limited to carb
Eintrag öffnenBosulif · 4.5 · CYP3A inhibitors The concomitant use of bosutinib with strong CYP3A inhibitors (including, but not limited to
Eintrag öffnenBosulif · 4.5 · Caution is warranted if mild CYP3A inducers are used concomitantly with bosutinib.
Eintrag öffnenBosulif · 4.5 · Caution should be exercised if mild CYP3A inhibitors are used concomitantly with bosutinib.
Eintrag öffnenBosulif · 4.5 · Effects of bosutinib on other medicinal products
Eintrag öffnenBosulif · 4.5 · Effects of other medicinal products on bosutinib
Eintrag öffnenBosulif · 4.5 · Following concomitant administration of a single dose bosutinib with 6 daily doses of 600 mg rifampicin, in 24
Eintrag öffnenBosulif · 4.5 · If a strong or moderate CYP3A inhibitor must be administered during bosutinib treatment, an interruption of bo
Eintrag öffnenBosulif · 4.5 · In a study of 20 healthy subjects, in whom a single dose of 125 mg aprepitant (a moderate CYP3A inhibitor) was
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