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Brinavess
Eintrag öffnenBrinavess · 4.1 Therapeutic indications · 1
Eintrag öffnenBrinavess · 4.3 Contraindications · 1
Eintrag öffnenBrinavess · 4.3 · • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. • Patients with
Eintrag öffnenBrinavess · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenBrinavess · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenBrinavess · 4.5 · Although vernakalant is a substrate of CYP2D6, population pharmacokinetic (PK) analyses demonstrated that no s
Eintrag öffnenBrinavess · 4.5 · No interaction studies have been performed.
Eintrag öffnenBrinavess · 4.5 · Vernakalant is a moderate, competitive inhibitor of CYP2D6. However, acute intravenous administration of verna
Eintrag öffnenBrinavess · 4.5 · Vernakalant must not be administered in patients who received intravenous AADs (class I and III) within 4 hour
Eintrag öffnenBrinavess · 4.5 · Within the clinical development program, oral maintenance antiarrhythmic therapy was halted for a minimum of 2
Eintrag öffnenBrinavess · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenBrinavess · 4.8 Undesirable effects · 1
Eintrag öffnenBrinavess · 4.8 · 7 Respiratory, thoracic and Very common: Sneezing mediastinal disorders Common: Cough; nasal discomfort
Eintrag öffnenBrinavess · 4.8 · 8 professionals are asked to report any suspected adverse reactions via the national reporting system listed i
Eintrag öffnenBrinavess · 4.8 · Atrial flutter Atrial fibrillation patients receiving vernakalant have a higher incidence of converting to atr
Eintrag öffnenBrinavess · 4.8 · Bradycardia Bradycardia was observed predominantly at the time of conversion to sinus rhythm. With a significa
Eintrag öffnenBrinavess · 4.8 · Clinically significant adverse reactions observed in clinical trials included hypotension and ventricular arrh
Eintrag öffnenBrinavess · 4.8 · Description of selected adverse reactions
Eintrag öffnenBrinavess · 4.8 · Eye disorders Uncommon: Lacrimation increased; eye irritation; visual impairment Cardiac disorders Common: Bra
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