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CPIC · CYP2D6, OPRM1, COMT, and Opioids
Eintrag öffnenCatechol-O-Methyltransferase-Inhibitoren
Eintrag öffnenComtan
Eintrag öffnenComtan · 4.1 Therapeutic indications · 1
Eintrag öffnenComtan · 4.3 Contraindications · 1
Eintrag öffnenComtan · 4.3 · - Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. - Hepatic impair
Eintrag öffnenComtan · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenComtan · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenComtan · 4.5 · 4 imipramine or between entacapone and moclobemide. Similarly, no interactions between entacapone and selegili
Eintrag öffnenComtan · 4.5 · Due to its affinity to cytochrome P450 2C9 in vitro (see section 5.2), entacapone may potentially interfere wi
Eintrag öffnenComtan · 4.5 · Entacapone binds to human albumin binding site II which also binds several other medicinal products, including
Eintrag öffnenComtan · 4.5 · Entacapone may be used with selegiline (a selective MAO-B inhibitor), but the daily dose of selegiline should
Eintrag öffnenComtan · 4.5 · Entacapone may form chelates with iron in the gastrointestinal tract. Entacapone and iron preparations should
Eintrag öffnenComtan · 4.5 · In single-dose studies in healthy volunteers, no interactions were observed between entacapone and
Eintrag öffnenComtan · 4.5 · No interaction of entacapone with carbidopa has been observed with the recommended treatment schedule. Pharmac
Eintrag öffnenComtan · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenComtan · 4.8 Undesirable effects · 1
Eintrag öffnenComtan · 4.8 · 6 General disorders and administration site conditions Common: Fatigue, sweating increased, fall Very rare: We
Eintrag öffnenComtan · 4.8 · Description of selected adverse reactions
Eintrag öffnenComtan · 4.8 · Dyskinesias (27%), nausea (11%), diarrhoea (8%), abdominal pain (7%) and dry mouth (4.2%) were reported signif
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