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Cabometyx
Eintrag öffnenCabometyx · 4.1 Therapeutic indications · 1
Eintrag öffnenCabometyx · 4.3 Contraindications · 1
Eintrag öffnenCabometyx · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenCabometyx · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenCabometyx · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenCabometyx · 4.5 · Administration of the strong CYP3A4 inducer rifampicin (600 mg daily for 31 days) to healthy volunteers increa
Eintrag öffnenCabometyx · 4.5 · Bile salt-sequestering agents Bile salt-sequestering agents such as colestyramine and cholestagel may interact
Eintrag öffnenCabometyx · 4.5 · CYP3A4 inhibitors and inducers Administration of the strong CYP3A4 inhibitor ketoconazole (400 mg daily for 27
Eintrag öffnenCabometyx · 4.5 · Effect of cabozantinib on other medicinal products The effect of cabozantinib on the pharmacokinetics of contr
Eintrag öffnenCabometyx · 4.5 · Effect of other medicinal products on cabozantinib
Eintrag öffnenCabometyx · 4.5 · Gastric pH modifying agents Co-administration of proton pump inhibitor (PPI) esomeprazole (40 mg daily for 6 d
Eintrag öffnenCabometyx · 4.5 · MRP2 inhibitors In vitro data demonstrate that cabozantinib is a substrate of MRP2. Therefore, administration
Eintrag öffnenCabometyx · 4.5 · P-glycoprotein substrates Cabozantinib was an inhibitor (IC50 = 7.0 μM), but not a substrate, of Pgp transport
Eintrag öffnenCabometyx · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenCabometyx · 4.8 Undesirable effects · 1
Eintrag öffnenCabometyx · 4.8 · 11 <1/10); uncommon (≥1/1,000 to <1/100); not known (cannot be estimated from the available data). Within each
Eintrag öffnenCabometyx · 4.8 · 12 Common proteinuria General disorders and administration site conditions Very common fatigue, mucosal inflam
Eintrag öffnenCabometyx · 4.8 · 13 Endocrine disorders Very common hypothyroidism, hyperthyroidism Common adrenal insufficiency Uncommon hypop
Eintrag öffnenCabometyx · 4.8 · 14 General disorders and administration site conditions Very common fatigue, pyrexia, oedema Common pain, ches
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