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Combivir
Eintrag öffnenCombivir · 4.1 Therapeutic indications · 1
Eintrag öffnenCombivir · 4.3 Contraindications · 1
Eintrag öffnenCombivir · 4.3 · Hypersensitivity to the active substances or to any of the excipients listed in section 6.1.
Eintrag öffnenCombivir · 4.3 · Zidovudine is contraindicated in patients with abnormally low neutrophil counts (<0.75 x 109/L), or abnormally
Eintrag öffnenCombivir · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenCombivir · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenCombivir · 4.5 · (organic cation transporter When concomitant inhibition) administration with co- Trimethoprim/sulfamethoxazole
Eintrag öffnenCombivir · 4.5 · 7 sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia (PCP) and toxoplasmosis have not been
Eintrag öffnenCombivir · 4.5 · 8 efficacy in case of combination in the clinical setting. Some clinical findings also support a possible inte
Eintrag öffnenCombivir · 4.5 · 9 these medicinal products is necessary then extra care should be taken in monitoring renal function and haema
Eintrag öffnenCombivir · 4.5 · Abbreviations: = Increase; =decrease; = no significant change; AUC=area under the concentration versus tim
Eintrag öffnenCombivir · 4.5 · Combivir contains lamivudine and zidovudine, therefore any interactions identified for these individually are
Eintrag öffnenCombivir · 4.5 · Concomitant treatment, especially acute therapy, with potentially nephrotoxic or myelosuppressive medicinal pr
Eintrag öffnenCombivir · 4.5 · Consideration should be given to replacing zidovudine in a combination ART regimen if this is already establis
Eintrag öffnenCombivir · 4.5 · Drugs by Therapeutic Area Interaction Recommendation Geometric mean change (%) concerning co- (Possible mechan
Eintrag öffnenCombivir · 4.5 · Exacerbation of anaemia due to ribavirin has been reported when zidovudine is part of the regimen used to trea
Eintrag öffnenCombivir · 4.5 · Interaction studies have only been performed in adults. The list below should not be considered exhaustive but
Eintrag öffnenCombivir · 4.5 · Lamivudine and zidovudine are not significantly metabolised by cytochrome P450 enzymes (such as CYP 3A4, CYP 2
Eintrag öffnenCombivir · 4.5 · Methadone dosage adjustment unlikely in majority of patients; occasionally methadone re-titration may be requi
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