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Conexxence
Eintrag öffnenConexxence · 4.1 Therapeutic indications · 1
Eintrag öffnenConexxence · 4.3 Contraindications · 1
Eintrag öffnenConexxence · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Hypocalcaemia (see
Eintrag öffnenConexxence · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenConexxence · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenConexxence · 4.5 · In an interaction study, denosumab did not affect the pharmacokinetics of midazolam, which is metabolised by c
Eintrag öffnenConexxence · 4.5 · In postmenopausal women with osteoporosis the pharmacokinetics and pharmacodynamics of denosumab were not alte
Eintrag öffnenConexxence · 4.5 · There are no clinical data on the co-administration of denosumab and hormone replacement therapy (oestrogen),
Eintrag öffnenConexxence · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenConexxence · 4.8 Undesirable effects · 1
Eintrag öffnenConexxence · 4.8 · Atypical fractures of the femur In the osteoporosis clinical trial program, atypical femoral fractures were re
Eintrag öffnenConexxence · 4.8 · Description of selected adverse reactions
Eintrag öffnenConexxence · 4.8 · Diverticulitis In a single phase III placebo-controlled clinical trial in patients with prostate cancer receiv
Eintrag öffnenConexxence · 4.8 · Drug-related hypersensitivity reactions In the post-marketing setting, rare events of drug-related hypersensit
Eintrag öffnenConexxence · 4.8 · Hypocalcaemia In two phase III placebo-controlled clinical trials in postmenopausal women with osteoporosis, a
Eintrag öffnenConexxence · 4.8 · In a pooled analysis of data from all phase II and phase III placebo-controlled studies, influenza-like illnes
Eintrag öffnenConexxence · 4.8 · In the post-marketing setting, rare cases of severe symptomatic hypocalcaemia resulting in hospitalisation, li
Eintrag öffnenConexxence · 4.8 · Lichenoid drug eruptions Lichenoid drug eruptions (e.g., lichen planus-like reactions) have been reported in p
Eintrag öffnenConexxence · 4.8 · MedDRA system organ class Frequency category Adverse reactions Infections and infestations Common Urinary trac
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