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Defitelio
Eintrag öffnenDefitelio · 4.1 Therapeutic indication · 1
Eintrag öffnenDefitelio · 4.3 Contraindications · 1
Eintrag öffnenDefitelio · 4.3 · − Hypersensitivity to the active substance or to any of the excipients listed in section 6.1 − Concomitant use
Eintrag öffnenDefitelio · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenDefitelio · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenDefitelio · 4.5 · Defibrotide does not inhibit or induce CYP450s (see section 5.2).
Eintrag öffnenDefitelio · 4.5 · Defibrotide has a profibrinolytic effect (see section 5.1) and this may potentially enhance the activity of an
Eintrag öffnenDefitelio · 4.5 · In a mouse model of thromboembolism, recombinant t-PA potentiated the antithrombotic effect of defibrotide whe
Eintrag öffnenDefitelio · 4.5 · Potential interactions with antithrombotic fibrinolytic agents
Eintrag öffnenDefitelio · 4.5 · Potential interactions with other medicinal products
Eintrag öffnenDefitelio · 4.5 · Potential interactions with recombinant t-PA
Eintrag öffnenDefitelio · 4.5 · There is currently no reported experience in patients on the concomitant treatment with Low Molecular Weight H
Eintrag öffnenDefitelio · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenDefitelio · 4.8 Undesirable effects · 1
Eintrag öffnenDefitelio · 4.8 · 5 Eye disorders Uncommon Conjunctival haemorrhage Vascular disorders Very common Hypotension Common Haemorrhag
Eintrag öffnenDefitelio · 4.8 · Adverse reactions observed are listed below, by system organ class and frequency. Within each frequency groupi
Eintrag öffnenDefitelio · 4.8 · Blood and lymphatic system disorders Common Coagulopathy Immune system disorders Uncommon Hypersensitivity Ana
Eintrag öffnenDefitelio · 4.8 · However there was no difference in incidence of serious bleeding or bleeding events with fatal outcome.
Eintrag öffnenDefitelio · 4.8 · In addition, although in the defibrotide studies in VOD there have been no reports of hypersensitivity, cases
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