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Efficib
Eintrag öffnenEfficib · 4.1 Therapeutic indications · 1
Eintrag öffnenEfficib · 4.3 Contraindications · 1
Eintrag öffnenEfficib · 4.3 · - hypersensitivity to the active substances or to any of the excipients listed in section 6.1 (see sections 4.
Eintrag öffnenEfficib · 4.3 · Efficib is contraindicated in patients with:
Eintrag öffnenEfficib · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenEfficib · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenEfficib · 4.5 · 6 Combinations requiring precautions for use Some medicinal products can adversely affect renal function, whic
Eintrag öffnenEfficib · 4.5 · 7 In vitro data suggest that sitagliptin does not inhibit nor induce CYP450 isoenzymes. In clinical studies, s
Eintrag öffnenEfficib · 4.5 · ACE-inhibitors may decrease the blood glucose levels. If necessary, the dose of the anti-hyperglycaemic medici
Eintrag öffnenEfficib · 4.5 · Alcohol Alcohol intoxication is associated with an increased risk of lactic acidosis, particularly in cases of
Eintrag öffnenEfficib · 4.5 · Ciclosporin: A study was conducted to assess the effect of ciclosporin, a potent inhibitor of p-glycoprotein,
Eintrag öffnenEfficib · 4.5 · Co-administration of multiple doses of sitagliptin (50 mg twice daily) and metformin (1 000 mg twice daily) di
Eintrag öffnenEfficib · 4.5 · Concomitant use not recommended
Eintrag öffnenEfficib · 4.5 · Concomitant use of medicinal products that interfere with common renal tubular transport systems involved in t
Eintrag öffnenEfficib · 4.5 · Effects of other medicinal products on sitagliptin In vitro and clinical data described below suggest that the
Eintrag öffnenEfficib · 4.5 · Effects of sitagliptin on other medicinal products Digoxin: Sitagliptin had a small effect on plasma digoxin c
Eintrag öffnenEfficib · 4.5 · Glucocorticoids (given by systemic and local routes) beta-2-agonists, and diuretics have intrinsic hyperglycae
Eintrag öffnenEfficib · 4.5 · In vitro studies indicated that the primary enzyme responsible for the limited metabolism of sitagliptin is CY
Eintrag öffnenEfficib · 4.5 · In vitro transport studies showed that sitagliptin is a substrate for p-glycoprotein and organic anion transpo
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