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Efient
Eintrag öffnenEfient · 4.1 Therapeutic indications · 1
Eintrag öffnenEfient · 4.3 Contraindications · 1
Eintrag öffnenEfient · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Active pathologica
Eintrag öffnenEfient · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenEfient · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenEfient · 4.5 · 5 Statins: Atorvastatin (80 mg daily) did not alter the pharmacokinetics of prasugrel and its inhibition of pl
Eintrag öffnenEfient · 4.5 · Effects of Efient on other medicinal products Digoxin: Prasugrel has no clinically significant effect on the p
Eintrag öffnenEfient · 4.5 · Effects of other medicinal products on Efient Acetylsalicylic acid: Efient is to be administered concomitantly
Eintrag öffnenEfient · 4.5 · Efient can be concomitantly administered with medicinal products metabolised by cytochrome P450 enzymes (inclu
Eintrag öffnenEfient · 4.5 · Heparin: A single intravenous bolus dose of unfractionated heparin (100 U/kg) did not significantly alter the
Eintrag öffnenEfient · 4.5 · Inducers of cytochromes P450: Rifampicin (600 mg daily), a potent inducer of CYP3A and CYP2B6, and an inducer
Eintrag öffnenEfient · 4.5 · Inhibitors of CYP3A: Ketoconazole (400 mg daily), a selective and potent inhibitor of CYP3A4 and CYP3A5, did n
Eintrag öffnenEfient · 4.5 · Medicinal products metabolised by CYP2B6: Prasugrel is a weak inhibitor of CYP2B6. In healthy subjects, prasug
Eintrag öffnenEfient · 4.5 · Medicinal products metabolised by CYP2C9: Prasugrel did not inhibit CYP2C9, as it did not affect the pharmacok
Eintrag öffnenEfient · 4.5 · Medicinal products that elevate gastric pH: Daily co-administration of ranitidine (an H2 blocker) or lansopraz
Eintrag öffnenEfient · 4.5 · Morphine and other opioids: A delayed and decreased exposure to oral P2Y12 inhibitors, including prasugrel and
Eintrag öffnenEfient · 4.5 · Non-steroidal anti-inflammatory drugs (NSAIDs): Concomitant administration with chronic NSAIDs has not been st
Eintrag öffnenEfient · 4.5 · Warfarin: Concomitant administration of Efient with coumarin derivatives other than warfarin has not been stud
Eintrag öffnenEfient · 4.6 Fertility, pregnancy and lactation · 1
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