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Enyglid
Eintrag öffnenEnyglid · 4.1 Therapeutic indications · 1
Eintrag öffnenEnyglid · 4.3 Contraindications · 1
Eintrag öffnenEnyglid · 4.3 · - Hypersensitivity to repaglinide or to any of the excipients listed in section 6.1. - Diabetes mellitus type
Eintrag öffnenEnyglid · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenEnyglid · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenEnyglid · 4.5 · A number of medicinal products are known to influence repaglinide metabolism, possible interactions should the
Eintrag öffnenEnyglid · 4.5 · Based on in vitro data, repaglinide appears to be a substrate for active hepatic uptake (organic anion transpo
Eintrag öffnenEnyglid · 4.5 · Co-administration of cimetidine, nifedipine, oestrogen, or simvastatin with repaglinide, all CYP3A4 substrates
Eintrag öffnenEnyglid · 4.5 · Co-administration of gemfibrozil (600 mg twice daily), an inhibitor of CYP2C8, and repaglinide (a single dose
Eintrag öffnenEnyglid · 4.5 · Co-administration of trimethoprim (160 mg twice daily), a moderate CYP2C8 inhibitor, and repaglinide (a single
Eintrag öffnenEnyglid · 4.5 · In a study conducted in healthy volunteers, the concomitant administration of repaglinide (a single dose of 0.
Eintrag öffnenEnyglid · 4.5 · In an interaction study with healthy volunteers, co-administration of clopidogrel (300 mg loading dose), a CYP
Eintrag öffnenEnyglid · 4.5 · In an interaction study with healthy volunteers, co-administration of deferasirox (30 mg/kg/day, 4 days), a mo
Eintrag öffnenEnyglid · 4.5 · In vitro data indicate that repaglinide is metabolised predominantly by CYP2C8, but also by CYP3A4. Clinical d
Eintrag öffnenEnyglid · 4.5 · No interaction studies have been performed in children and adolescents.
Eintrag öffnenEnyglid · 4.5 · Paediatric population
Eintrag öffnenEnyglid · 4.5 · Repaglinide had no clinically relevant effect on the pharmacokinetic properties of digoxin, theophylline or wa
Eintrag öffnenEnyglid · 4.5 · Rifampicin, a potent inducer of CYP3A4, but also CYP2C8, acts both as an inducer and inhibitor of the metaboli
Eintrag öffnenEnyglid · 4.5 · The following substances may enhance and/or prolong the hypoglycaemic effect of repaglinide: Gemfibrozil, clar
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