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Epidyolex
Eintrag öffnenEpidyolex · 4.1 Therapeutic indications · 1
Eintrag öffnenEpidyolex · 4.3 Contraindications · 1
Eintrag öffnenEpidyolex · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenEpidyolex · 4.3 · Patients with transaminase elevations greater than 3 times the upper limit of normal (ULN) and bilirubin great
Eintrag öffnenEpidyolex · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenEpidyolex · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenEpidyolex · 4.5 · 7 Clobazam When cannabidiol and clobazam are co-administered, bi-directional PK interactions occur. Based on a
Eintrag öffnenEpidyolex · 4.5 · 8 (compared to bupropion administered alone), which is within the observed variability and therefore not clini
Eintrag öffnenEpidyolex · 4.5 · CYP3A4 or CYP2C19 inducers
Eintrag öffnenEpidyolex · 4.5 · Cannabidiol is a substrate for UGT1A7, UGT1A9 and UGT2B7. No formal drug-drug interaction studies have been co
Eintrag öffnenEpidyolex · 4.5 · Concomitant AED treatments
Eintrag öffnenEpidyolex · 4.5 · Concomitant use of cannabidiol and valproate increases the incidence of diarrhoea and events of decreased appe
Eintrag öffnenEpidyolex · 4.5 · Everolimus Coadministration of cannabidiol (12.5 mg/kg twice daily) with the P-gp and CYP3A4 substrate everoli
Eintrag öffnenEpidyolex · 4.5 · In vitro assessment of interaction with UGT enzymes The metabolite 7-carboxy-cannabidiol (7-COOH-CBD) is an in
Eintrag öffnenEpidyolex · 4.5 · Potential for cannabidiol to affect other medicinal products
Eintrag öffnenEpidyolex · 4.5 · Sensitive CYP2B6 substrates Coadministration of cannabidiol (7.5 mg/kg twice daily) with a single dose of bupr
Eintrag öffnenEpidyolex · 4.5 · Sensitive CYP2C19 substrates In vitro data have demonstrated that cannabidiol inhibits CYP2C19, which may caus
Eintrag öffnenEpidyolex · 4.5 · Sensitive CYP2C8 substrates Because of potential inhibition of enzyme activity, dose reduction of substrates o
Eintrag öffnenEpidyolex · 4.5 · Sensitive CYP2C9 substrates Coadministration of cannabidiol (7.5 mg/kg twice daily) with a single dose of tolb
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