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Esbriet
Eintrag öffnenEsbriet · 4.1 Therapeutic indications · 1
Eintrag öffnenEsbriet · 4.3 Contraindications · 1
Eintrag öffnenEsbriet · 4.3 · ● Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. ● History of ang
Eintrag öffnenEsbriet · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenEsbriet · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenEsbriet · 4.5 · 5 Esbriet therapy due to the reduced clearance of pirfenidone. Other therapies that are inhibitors of both CYP
Eintrag öffnenEsbriet · 4.5 · A Phase 1 interaction study evaluated the effect of cigarette smoking (CYP1A2 inducer) on the pharmacokinetics
Eintrag öffnenEsbriet · 4.5 · Approximately 70–80% of pirfenidone is metabolised via CYP1A2 with minor contributions from other CYP isoenzym
Eintrag öffnenEsbriet · 4.5 · Cigarette smoking and inducers of CYP1A2
Eintrag öffnenEsbriet · 4.5 · Co-administration of Esbriet and 750 mg of ciprofloxacin (a moderate inhibitor of CYP1A2) increased the exposu
Eintrag öffnenEsbriet · 4.5 · Co-administration of medicinal products that act as potent inducers of both CYP1A2 and the other CYP isoenzyme
Eintrag öffnenEsbriet · 4.5 · Consumption of grapefruit juice is associated with inhibition of CYP1A2 and should be avoided during treatment
Eintrag öffnenEsbriet · 4.5 · Esbriet is contraindicated in patients with concomitant use of fluvoxamine (see section 4.3). Fluvoxamine shou
Eintrag öffnenEsbriet · 4.5 · Esbriet should be used with caution in patients treated with other moderate inhibitors of CYP1A2 (e.g. amiodar
Eintrag öffnenEsbriet · 4.5 · Fluvoxamine and inhibitors of CYP1A2
Eintrag öffnenEsbriet · 4.5 · In a Phase 1 study, the co-administration of Esbriet and fluvoxamine (a strong inhibitor of CYP1A2 with inhibi
Eintrag öffnenEsbriet · 4.5 · In the case of moderate inducers of CYP1A2 (e.g. omeprazole), concomitant use may theoretically result in a lo
Eintrag öffnenEsbriet · 4.5 · Special care should also be exercised if CYP1A2 inhibitors are being used concomitantly with potent inhibitors
Eintrag öffnenEsbriet · 4.6 Fertility, pregnancy and lactation · 1
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