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Etcamah
Eintrag öffnenEtcamah · 4.1 Therapeutic indications · 1
Eintrag öffnenEtcamah · 4.3 Contraindications · 1
Eintrag öffnenEtcamah · 4.3 · Breast-feeding (see section 4.6).
Eintrag öffnenEtcamah · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenEtcamah · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenEtcamah · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenEtcamah · 4.5 · 5 Effects of camizestrant on other medicinal products
Eintrag öffnenEtcamah · 4.5 · 6 be avoided. All other CYP2B6 substrates are permitted but caution should be exercised and patients monitored
Eintrag öffnenEtcamah · 4.5 · BCRP sensitive substrates In vitro data show that camizestrant is an inhibitor of Breast Cancer Resistance Pro
Eintrag öffnenEtcamah · 4.5 · CYP2B6 sensitive substrates In vitro data show that camizestrant is an inhibitor of Cytochrome P450 2B6 (CYP2B
Eintrag öffnenEtcamah · 4.5 · CYP2C9 and CYP2C19 substrates In vitro data in conjunction with mechanistic static modelling show that camizes
Eintrag öffnenEtcamah · 4.5 · CYP3A4/5 inducers The exposure to camizestrant is expected to decrease if co-administered with moderate and st
Eintrag öffnenEtcamah · 4.5 · CYP3A4/5 inhibitors In a clinical study, concomitant use of itraconazole, a strong CYP3A4/5 inhibitor, increas
Eintrag öffnenEtcamah · 4.5 · CYP3A4/5 substrates In a clinical study, concomitant use of camizestrant increased midazolam, a sensitive CYP3
Eintrag öffnenEtcamah · 4.5 · Camizestrant in combination with ribociclib has been studied clinically, a non-fatal Torsades de Pointes was o
Eintrag öffnenEtcamah · 4.5 · Camizestrant is a reversible inhibitor of CYP3A4/5 and CYP2B6 and cause inhibition of drug transporters P-gp,
Eintrag öffnenEtcamah · 4.5 · Effects of other medicinal products on camizestrant
Eintrag öffnenEtcamah · 4.5 · Medicinal products known to prolong the QT interval
Eintrag öffnenEtcamah · 4.5 · OATP1B1 sensitive substrates In vitro data show that camizestrant is an inhibitor of OATP1B1. Therefore, camiz
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