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Clofarabin
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Eintrag öffnenEvoltra · 4.1 Therapeutic indications · 1
Eintrag öffnenEvoltra · 4.3 Contraindications · 1
Eintrag öffnenEvoltra · 4.3 · Breast-feeding (see section 4.6).
Eintrag öffnenEvoltra · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenEvoltra · 4.3 · Use in patients with severe renal insufficiency or severe hepatic impairment.
Eintrag öffnenEvoltra · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenEvoltra · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenEvoltra · 4.5 · 6 Clofarabine is predominately excreted via the kidneys. Thus, the concomitant use of medicinal products that
Eintrag öffnenEvoltra · 4.5 · Clofarabine is not detectably metabolised by the cytochrome P450 (CYP) enzyme system. Therefore, it is unlikel
Eintrag öffnenEvoltra · 4.5 · No interaction studies have been performed. However, there are no known clinically significant interactions wi
Eintrag öffnenEvoltra · 4.5 · Patients taking medicinal products known to affect blood pressure or cardiac function should be closely monito
Eintrag öffnenEvoltra · 4.5 · The liver is a potential target organ for toxicity. Thus, the concomitant use of medicinal products that have
Eintrag öffnenEvoltra · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenEvoltra · 4.8 Undesirable effects · 1
Eintrag öffnenEvoltra · 4.8 · 10 Systemic inflammatory response syndrome (SIRS) or capillary leak syndrome SIRS, capillary leak syndrome (si
Eintrag öffnenEvoltra · 4.8 · 8 Common: Hypotension*, capillary leak syndrome, haematoma Respiratory, thoracic and mediastinal Common: Respi
Eintrag öffnenEvoltra · 4.8 · 9 which were considered to be serious; see section 4.4). However, the majority of these hypotensive events wer
Eintrag öffnenEvoltra · 4.8 · Adverse reactions are listed by system organ class and frequency (very common (≥ 1/10); common (≥ 1/100 to < 1
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