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Farydak
Eintrag öffnenFarydak · 4.1 Therapeutic indications · 1
Eintrag öffnenFarydak · 4.3 Contraindications · 1
Eintrag öffnenFarydak · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Breast-feeding (se
Eintrag öffnenFarydak · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenFarydak · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenFarydak · 4.5 · 11 Agents that are predicted to decrease panobinostat concentrations
Eintrag öffnenFarydak · 4.5 · Agents that may increase panobinostat plasma concentrations
Eintrag öffnenFarydak · 4.5 · Agents whose plasma concentrations may be increased by panobinostat
Eintrag öffnenFarydak · 4.5 · Agents whose plasma exposure can be decreased by panobinostat
Eintrag öffnenFarydak · 4.5 · Anticipated pharmacodynamic interactions
Eintrag öffnenFarydak · 4.5 · Co-administration of a single 20 mg panobinostat dose with ketoconazole, a strong CYP3A inhibitor, increased t
Eintrag öffnenFarydak · 4.5 · Farydak metabolism is through both non-CYP and CYP mediated routes. Approximately 40% of panobinostat is metab
Eintrag öffnenFarydak · 4.5 · Hormonal contraceptives It is currently unknown whether panobinostat may reduce the effectiveness of hormonal
Eintrag öffnenFarydak · 4.5 · In patients who take concomitant medicinal products which are strong CYP3A and/or Pgp inhibitors, including, b
Eintrag öffnenFarydak · 4.5 · No data is available that can be used to exclude the risk that panobinostat could be a weak inducer of the enz
Eintrag öffnenFarydak · 4.5 · Panobinostat increased the Cmax and the AUC of dextromethorphan (a substrate of CYP2D6) by 1.8- and 1.6-fold,
Eintrag öffnenFarydak · 4.5 · Patients should be instructed to avoid star fruit, grapefruit, grapefruit juice, pomegranates and pomegranate
Eintrag öffnenFarydak · 4.5 · Prolongation of QT interval Based on preclinical and clinical data, panobinostat has the potential to prolong
Eintrag öffnenFarydak · 4.5 · The panobinostat fraction metabolised through CYP3A4 is approximately 40%. In clinical studies in multiple mye
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