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Eintrag öffnenFotivda · 4.1 Therapeutic indications · 1
Eintrag öffnenFotivda · 4.3 Contraindications · 1
Eintrag öffnenFotivda · 4.3 · Co-administration with herbal preparations containing St. John’s wort (Hypericum perforatum) (see section 4.5)
Eintrag öffnenFotivda · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenFotivda · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenFotivda · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenFotivda · 4.5 · CYP3A4 inhibitors In a clinical study in healthy volunteers, co-administration of tivozanib with a potent CYP3
Eintrag öffnenFotivda · 4.5 · Contraceptives It is currently unknown whether tivozanib may reduce the effectiveness of hormonal contraceptiv
Eintrag öffnenFotivda · 4.5 · Contraindication of concomitant use Herbal preparations containing St. John's wort (Hypericum perforatum) are
Eintrag öffnenFotivda · 4.5 · Medicinal products for which intestinal absorption is restricted by BCRP Tivozanib inhibits the transporter pr
Eintrag öffnenFotivda · 4.5 · Strong CYP3A4 inducers In a clinical study in healthy volunteers, co-administration of a single 1340 microgram
Eintrag öffnenFotivda · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenFotivda · 4.8 Undesirable effects · 1
Eintrag öffnenFotivda · 4.8 · 10 Venous thromboembolism Pulmonary embolism was reported in patients (0.7%) receiving tivozanib as initial th
Eintrag öffnenFotivda · 4.8 · 7 Table 1: Tabulated list of adverse reactions (presented using frequencies for all-causality adverse events)
Eintrag öffnenFotivda · 4.8 · 8 System Very common Common Uncommon Rare Not known Organ Class Gastrointestinal Abdominal pain15 Pancreatitis
Eintrag öffnenFotivda · 4.8 · 9 System Very common Common Uncommon Rare Not known Organ Class Investigations Weight decreased Amylase increa
Eintrag öffnenFotivda · 4.8 · Adverse reactions occurring in patients who continued to receive tivozanib as their initial on trial therapy i
Eintrag öffnenFotivda · 4.8 · Arterial thromboembolic events Arterial thromboembolic adverse reactions in the patients receiving tivozanib a
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