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Eintrag öffnenHerwenda · 4.1 Therapeutic indications · 1
Eintrag öffnenHerwenda · 4.3 Contraindications · 1
Eintrag öffnenHerwenda · 4.3 · • Hypersensitivity to the active substance, murine proteins, or to any of the excipients listed in section 6.1
Eintrag öffnenHerwenda · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenHerwenda · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenHerwenda · 4.5 · 9 Pharmacokinetic data from Study H4613g/GO01305 suggested that carboplatin had no impact on the PK of trastuz
Eintrag öffnenHerwenda · 4.5 · By comparison of simulated serum trastuzumab concentrations after trastuzumab monotherapy (4 mg/kg loading/2 m
Eintrag öffnenHerwenda · 4.5 · Comparison of PK results from two phase II studies (BO15935 and M77004) and one phase III study (H0648g) in wh
Eintrag öffnenHerwenda · 4.5 · Data from study JP16003, a single-arm study of trastuzumab (4 mg/kg intravenous loading dose and 2 mg/kg intra
Eintrag öffnenHerwenda · 4.5 · Effect of antineoplastic agents on trastuzumab pharmacokinetics
Eintrag öffnenHerwenda · 4.5 · Effect of trastuzumab on the pharmacokinetics of other antineoplastic agents
Eintrag öffnenHerwenda · 4.5 · No formal drug interaction studies have been performed. Clinically significant interactions between trastuzuma
Eintrag öffnenHerwenda · 4.5 · Pharmacokinetic data from Study H4613g/GO01305 in patients with metastatic or locally advanced inoperable HER2
Eintrag öffnenHerwenda · 4.5 · Pharmacokinetic data from studies BO15935 and M77004 in women with HER2 positive MBC suggested that exposure t
Eintrag öffnenHerwenda · 4.5 · The administration of concomitant anastrozole did not appear to influence the pharmacokinetics of trastuzumab.
Eintrag öffnenHerwenda · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenHerwenda · 4.8 Undesirable effects · 1
Eintrag öffnenHerwenda · 4.8 · 11 System organ class Adverse reaction Frequency Depression Common 1 Nervous system disorders Tremor Very comm
Eintrag öffnenHerwenda · 4.8 · 12 System organ class Adverse reaction Frequency Vomiting Very common Nausea Very common 1 Lip swelling Very c
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