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Topotecan Hospira
Eintrag öffnenTopotecan Hospira · 4.1 Therapeutic indications · 1
Eintrag öffnenTopotecan Hospira · 4.3 Contraindications · 1
Eintrag öffnenTopotecan Hospira · 4.3 · − Severe hypersensitivity to the active substance or to any of the excipients. − Breast-feeding (see section 4
Eintrag öffnenTopotecan Hospira · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenTopotecan Hospira · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenTopotecan Hospira · 4.5 · No in vivo human pharmacokinetic interaction studies have been performed.
Eintrag öffnenTopotecan Hospira · 4.5 · Topotecan does not inhibit human P450 enzymes (see section 5.2). In a population study using the intravenous r
Eintrag öffnenTopotecan Hospira · 4.5 · When combining topotecan with other chemotherapy agents, reduction of the doses of each medicinal product may
Eintrag öffnenTopotecan Hospira · 4.5 · When topotecan (0.75 mg/m2/day for 5 consecutive days) and cisplatin (60 mg/m2/day on day 1) were administered
Eintrag öffnenTopotecan Hospira · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenTopotecan Hospira · 4.8 Undesirable effects · 1
Eintrag öffnenTopotecan Hospira · 4.8 · 6 Metabolism and nutrition disorders Very common Anorexia (which may be severe) Respiratory, thoracic and medi
Eintrag öffnenTopotecan Hospira · 4.8 · 7 Non-haematological
Eintrag öffnenTopotecan Hospira · 4.8 · Additional adverse events were seen when topotecan was given in combination with cisplatin; however, these eve
Eintrag öffnenTopotecan Hospira · 4.8 · Adverse reactions are listed below by system organ class and absolute frequency (all reported events). Frequen
Eintrag öffnenTopotecan Hospira · 4.8 · Anaemia Moderate to severe (Hb ≤8.0 g/dl) in 37% of patients (14% of courses). Red cell transfusions were give
Eintrag öffnenTopotecan Hospira · 4.8 · Common Hypersensitivity reaction including rash Rare Anaphylactic reaction, angioedema, urticaria
Eintrag öffnenTopotecan Hospira · 4.8 · Fatigue was observed in approximately 25% and asthenia in 16% of patients receiving topotecan. Severe (Grade 3
Eintrag öffnenTopotecan Hospira · 4.8 · Frequently reported non-haematological effects were gastrointestinal, such as nausea (52%), vomiting (32%), di
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