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Hycamtin
Eintrag öffnenHycamtin · 4.1 Therapeutic indications · 1
Eintrag öffnenHycamtin · 4.1 Therapeutic indications · 2
Eintrag öffnenHycamtin · 4.3 Contraindications · 1
Eintrag öffnenHycamtin · 4.3 Contraindications · 2
Eintrag öffnenHycamtin · 4.3 · 17 neutrophils <1.5 x 109/l and/or a platelet count of 100 x 109/l.
Eintrag öffnenHycamtin · 4.3 · − Severe hypersensitivity to the active substance or to any of the excipients. − Breast-feeding (see section 4
Eintrag öffnenHycamtin · 4.3 · − Severe hypersensitivity to the active substance or to any of the excipients. − Breast-feeding (see section 4
Eintrag öffnenHycamtin · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenHycamtin · 4.4 Special warnings and precautions for use · 2
Eintrag öffnenHycamtin · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenHycamtin · 4.5 Interaction with other medicinal products and other forms of interaction · 2
Eintrag öffnenHycamtin · 4.5 · Cyclosporin A (an inhibitor of ABCB1, ABCC1 [MRP-1], and CYP3A4) administered with oral topotecan increased to
Eintrag öffnenHycamtin · 4.5 · No in vivo human pharmacokinetic interaction studies have been performed.
Eintrag öffnenHycamtin · 4.5 · No in vivo human pharmacokinetic interaction studies have been performed.
Eintrag öffnenHycamtin · 4.5 · Patients should be carefully monitored for adverse reactions when oral topotecan is administered with a substa
Eintrag öffnenHycamtin · 4.5 · The pharmacokinetics of topotecan were generally unchanged when co-administered with ranitidine.
Eintrag öffnenHycamtin · 4.5 · Topotecan does not inhibit human P450 enzymes (see section 5.2). In a population study using the intravenous r
Eintrag öffnenHycamtin · 4.5 · Topotecan does not inhibit human P450 enzymes (see section 5.2). In a population study using the intravenous r
Eintrag öffnenHycamtin · 4.5 · Topotecan is a substrate for both ABCB1 (P-glycoprotein) and ABCG2 (BCRP). Inhibitors of ABCB1 and ABCG2 admin
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