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Axitinib
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Eintrag öffnenInlyta · 4.1 Therapeutic indications · 1
Eintrag öffnenInlyta · 4.3 Contraindications · 1
Eintrag öffnenInlyta · 4.3 · Hypersensitivity to axitinib or to any of the excipients listed in section 6.1.
Eintrag öffnenInlyta · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenInlyta · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenInlyta · 4.5 · 7 no or minimal CYP3A4/5 induction potential is recommended. If a strong CYP3A4/5 inducer must be co-administe
Eintrag öffnenInlyta · 4.5 · CYP1A2 and CYP2C19 inhibitors CYP1A2 and CYP2C19 constitute minor (< 10%) pathways in axitinib metabolism. The
Eintrag öffnenInlyta · 4.5 · CYP3A4/5 inducers Rifampicin, a strong inducer of CYP3A4/5, administered at a dose of 600 mg once daily for 9
Eintrag öffnenInlyta · 4.5 · CYP3A4/5 inhibitors Ketoconazole, a strong inhibitor of CYP3A4/5, administered at a dose of 400 mg once daily
Eintrag öffnenInlyta · 4.5 · Co-administration of axitinib with strong CYP3A4/5 inducers (e.g. rifampicin, dexamethasone, phenytoin, carbam
Eintrag öffnenInlyta · 4.5 · In vitro data indicate that axitinib is metabolised primarily by CYP3A4/5 and, to a lesser extent, CYP1A2, CYP
Eintrag öffnenInlyta · 4.5 · In vitro studies also indicated that axitinib has the potential to inhibit CYP2C8. However, co-administration
Eintrag öffnenInlyta · 4.5 · In vitro studies in human hepatocytes also indicated that axitinib does not induce CYP1A1, CYP1A2, or CYP3A4/5
Eintrag öffnenInlyta · 4.5 · In vitro studies indicated that axitinib has a potential to inhibit CYP1A2. Therefore, co-administration of ax
Eintrag öffnenInlyta · 4.5 · In vitro studies of CYP and UGT inhibition and induction In vitro studies indicated that axitinib does not inh
Eintrag öffnenInlyta · 4.5 · In vitro studies with P-glycoprotein In vitro studies indicated that axitinib inhibits P-glycoprotein. However
Eintrag öffnenInlyta · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenInlyta · 4.8 Undesirable effects · 1
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