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Jardiance
Eintrag öffnenJardiance · 4.1 Therapeutic indications · 1
Eintrag öffnenJardiance · 4.3 Contraindications · 1
Eintrag öffnenJardiance · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenJardiance · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenJardiance · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenJardiance · 4.5 · 7 interactions involving the major CYP450 and UGT isoforms with empagliflozin and concomitantly administered s
Eintrag öffnenJardiance · 4.5 · An interaction study with gemfibrozil, an in vitro inhibitor of OAT3 and OATP1B1/1B3 transporters, showed that
Eintrag öffnenJardiance · 4.5 · Based on in vitro studies, empagliflozin does not inhibit, inactivate, or induce CYP450 isoforms. Empagliflozi
Eintrag öffnenJardiance · 4.5 · Co-administration of empagliflozin with probenecid, an inhibitor of UGT enzymes and OAT3, resulted in a 26% in
Eintrag öffnenJardiance · 4.5 · Diuretics Empagliflozin may add to the diuretic effect of thiazide and loop diuretics and may increase the ris
Eintrag öffnenJardiance · 4.5 · Effects of empagliflozin on other medicinal products Empagliflozin may increase renal lithium excretion and th
Eintrag öffnenJardiance · 4.5 · Effects of other medicinal products on empagliflozin In vitro data suggest that the primary route of metabolis
Eintrag öffnenJardiance · 4.5 · Empagliflozin does not inhibit P-gp at therapeutic doses. Based on in vitro studies, empagliflozin is consider
Eintrag öffnenJardiance · 4.5 · Empagliflozin does not inhibit human uptake transporters such as OAT3, OATP1B1, and OATP1B3 in vitro at clinic
Eintrag öffnenJardiance · 4.5 · Empagliflozin exposure was similar with and without co-administration with verapamil, a P-gp inhibitor, indica
Eintrag öffnenJardiance · 4.5 · Inhibition of OATP1B1/1B3 transporters by co-administration with rifampicin resulted in a 75% increase in Cmax
Eintrag öffnenJardiance · 4.5 · Insulin and insulin secretagogues Insulin and insulin secretagogues, such as sulphonylureas, may increase the
Eintrag öffnenJardiance · 4.5 · Interaction studies conducted in healthy volunteers suggest that empagliflozin had no clinically relevant effe
Eintrag öffnenJardiance · 4.5 · Interaction studies have only been performed in adults.
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