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Javlor
Eintrag öffnenJavlor · 4.1 Therapeutic indications · 1
Eintrag öffnenJavlor · 4.3 Contraindications · 1
Eintrag öffnenJavlor · 4.3 · Hypersensitivity to the active substance or other vinca alkaloids. Recent (within 2 weeks) or current severe i
Eintrag öffnenJavlor · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenJavlor · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenJavlor · 4.5 · A pharmacokinetic interaction between vinflunine and pegylated/liposomal doxorubicin was observed, resulting i
Eintrag öffnenJavlor · 4.5 · A phase I study evaluating the effect of ketoconazole treatment (a potent CYP3A4 inhibitor) on vinflunine phar
Eintrag öffnenJavlor · 4.5 · A possible interaction with paclitaxel and docetaxel (CYP3 substrates) has been suggested from an in vitro stu
Eintrag öffnenJavlor · 4.5 · In vitro studies showed that vinflunine had neither inducing effects on CYP1A2, CYP2B6 or CYP3A4 activity nor
Eintrag öffnenJavlor · 4.5 · In vitro studies showed that vinflunine is a Pgp-substrate like other vinca alkaloids, but with a lower affini
Eintrag öffnenJavlor · 4.5 · The concomitant use of opioids could enhance the risk of constipation.
Eintrag öffnenJavlor · 4.5 · The concomitant use of vinflunine with others QT/QTc interval prolonging medicinal products should be avoided
Eintrag öffnenJavlor · 4.5 · Therefore the concomitant use of vinflunine and potent CYP3A4 inhibitors (such as ritonavir, ketoconazole, itr
Eintrag öffnenJavlor · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenJavlor · 4.8 Undesirable effects · 1
Eintrag öffnenJavlor · 4.8 · 10 CTC version 2.0) was observed in 5.2% of patients. Infection with Grade 3/4 neutropenia was observed in 2.8
Eintrag öffnenJavlor · 4.8 · 8 Table 4 Adverse reactions observed in patients with transitional cell carcinoma of the urothelium treated wi
Eintrag öffnenJavlor · 4.8 · Adverse reactions in all indications Adverse reactions occurring in patients with transitional cell carcinoma
Eintrag öffnenJavlor · 4.8 · Blood and lymphatic system disorders Grade 3/4 neutropenia was observed in 43.8% of patients. Severe anaemia a
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