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Jevtana
Eintrag öffnenJevtana · 4.1 Therapeutic indications · 1
Eintrag öffnenJevtana · 4.3 Contraindications · 1
Eintrag öffnenJevtana · 4.3 · • Hypersensitivity to cabazitaxel, to other taxanes, to polysorbate 80 or to any of the excipients listed in s
Eintrag öffnenJevtana · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenJevtana · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenJevtana · 4.5 · 6 Repeated administration of ketoconazole (400 mg once daily), a strong CYP3A inhibitor, resulted in a 20% dec
Eintrag öffnenJevtana · 4.5 · CYP3A inducers Repeated administration of rifampin (600 mg once daily), a strong CYP3A inducer, resulted in an
Eintrag öffnenJevtana · 4.5 · CYP3A inhibitors
Eintrag öffnenJevtana · 4.5 · Concomitant administration of aprepitant, a moderate CYP3A inhibitor, had no effect on cabazitaxel clearance.
Eintrag öffnenJevtana · 4.5 · In vitro studies have shown that cabazitaxel is mainly metabolised through CYP3A (80% to 90%) (see section 5.2
Eintrag öffnenJevtana · 4.5 · OATP1B1 In vitro, cabazitaxel has also been shown to inhibit the transport proteins of the Organic Anion Trans
Eintrag öffnenJevtana · 4.5 · Vaccinations Administration of live or live-attenuated vaccines in patients immunocompromised by chemotherapeu
Eintrag öffnenJevtana · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenJevtana · 4.8 Undesirable effects · 1
Eintrag öffnenJevtana · 4.8 · 10 System Organ Adverse reaction All grades Grade>3 Class n (%) n (%) Very Common Uncommon common Peripheral o
Eintrag öffnenJevtana · 4.8 · 11 Respiratory disorders Cases of interstitial pneumonia/pneumonitis and interstitial lung disease, sometimes
Eintrag öffnenJevtana · 4.8 · 8 System Organ Adverse reaction All grades Grade>3 Class n (%) n (%) Very Common Uncommon common Upper respira
Eintrag öffnenJevtana · 4.8 · 9 System Organ Adverse reaction All grades Grade>3 Class n (%) n (%) Very Common Uncommon common Diarrhoea 460
Eintrag öffnenJevtana · 4.8 · Cardiac disorders and arrhythmias In the pooled analysis, cardiac events were reported in 5.5% of the patients
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