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Interleukin-1-Rezeptor-Antagonist-Protein
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Eintrag öffnenKineret · 4.1 Therapeutic indications · 1
Eintrag öffnenKineret · 4.3 Contraindications · 1
Eintrag öffnenKineret · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1 or to E. coli deriv
Eintrag öffnenKineret · 4.3 · Kineret treatment must not be initiated in patients with neutropenia (ANC <1.5 x 109/l) (see section 4.4).
Eintrag öffnenKineret · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenKineret · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenKineret · 4.5 · Concurrent Kineret and TNF-α antagonist treatment In a clinical study with RA patients receiving background me
Eintrag öffnenKineret · 4.5 · Cytochrome P450 Substrates The formation of CYP450 enzymes is suppressed by increased levels of cytokines (e.g
Eintrag öffnenKineret · 4.5 · For information on vaccinations see section 4.4.
Eintrag öffnenKineret · 4.5 · Interactions between Kineret and other medicinal products have not been investigated in formal studies. In cli
Eintrag öffnenKineret · 4.5 · The concurrent use of Kineret with etanercept or any other TNF-α antagonist is not recommended (see section 4.
Eintrag öffnenKineret · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenKineret · 4.8 Undesirable effects · 1
Eintrag öffnenKineret · 4.8 · 10 In the clinical study in COVID-19, events of neutropenia were reported in 3.0% of Kineret-treated patients
Eintrag öffnenKineret · 4.8 · 11 Hepatic Events In clinical studies transient elevations of liver enzymes have been seen. These elevations h
Eintrag öffnenKineret · 4.8 · 12 Paediatric population Kineret has been studied in 36 patients with CAPS, 21 patients with SJIA and 71 patie
Eintrag öffnenKineret · 4.8 · 8 Adverse reactions data in COVID-19 are based on a randomized placebo-controlled study of 405 Kineret-treated
Eintrag öffnenKineret · 4.8 · 9 MedDRA Organ System Frequency Undesirable Effect Infections and infestations Common (≥ 1/100 to < 1/10) Seri
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