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Krazati
Eintrag öffnenKrazati · 4.1 Therapeutic indications · 1
Eintrag öffnenKrazati · 4.3 Contraindications · 1
Eintrag öffnenKrazati · 4.3 · Concomitant use of CYP3A substrates with a narrow therapeutic index (see sections 4.4 and 4.5).
Eintrag öffnenKrazati · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenKrazati · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenKrazati · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenKrazati · 4.5 · 5 to increase oral midazolam AUC by 31-fold. Avoid concomitant use of adagrasib with sensitive CYP3A substrate
Eintrag öffnenKrazati · 4.5 · Breast cancer resistance protein (BCRP) or organic anion-transporting polypeptides 1B1 (OATP1B1) substrates No
Eintrag öffnenKrazati · 4.5 · CYP2C9 substrates: In vitro, adagrasib inhibits CYP2C9. Avoid concomitant use of adagrasib with sensitive CYP2
Eintrag öffnenKrazati · 4.5 · CYP2D6 substrates: Co-administration of dextromethorphan (a sensitive CYP2D6 substrate) with multiple doses of
Eintrag öffnenKrazati · 4.5 · Effects of adagrasib on other medicinal products
Eintrag öffnenKrazati · 4.5 · Effects of other medicinal products on adagrasib
Eintrag öffnenKrazati · 4.5 · In vitro studies showed that adagrasib is metabolised primarily by CYP3A4 and is a reversible inhibitor of CYP
Eintrag öffnenKrazati · 4.5 · Medicinal products that prolong the QTc interval
Eintrag öffnenKrazati · 4.5 · P-glycoprotein (P-gp) substrates Administration of adagrasib 600 mg single dose increased digoxin (a P-gp subs
Eintrag öffnenKrazati · 4.5 · Strong CYP3A inducers Co-administration of multiple doses of rifampicin 600 mg QD (strong CYP3A4 inducer) with
Eintrag öffnenKrazati · 4.5 · Strong CYP3A inhibitors Adagrasib Cmax increased by 2.4-fold and AUC increased by 4-fold following concomitant
Eintrag öffnenKrazati · 4.5 · Substrates of cytochrome P450 (CYP) enzymes CYP3A4 substrates: Co-administration of oral midazolam (a sensitiv
Eintrag öffnenKrazati · 4.5 · The effect of co-administration of medicinal products known to prolong the QTc interval with adagrasib is unkn
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