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Leflunomide medac
Eintrag öffnenLeflunomide medac · 4.1 Therapeutic indications · 1
Eintrag öffnenLeflunomide medac · 4.3 Contraindications · 1
Eintrag öffnenLeflunomide medac · 4.3 · 3 • Patients with significantly impaired bone marrow function or significant anaemia, leucopenia, neutropenia
Eintrag öffnenLeflunomide medac · 4.3 · • Breast-feeding women (see section 4.6).
Eintrag öffnenLeflunomide medac · 4.3 · • Hypersensitivity (especially previous Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multifo
Eintrag öffnenLeflunomide medac · 4.3 · • Patients with impairment of liver function.
Eintrag öffnenLeflunomide medac · 4.3 · • Patients with moderate to severe renal insufficiency, because insufficient clinical experience is available
Eintrag öffnenLeflunomide medac · 4.3 · • Patients with serious infections (see section 4.4).
Eintrag öffnenLeflunomide medac · 4.3 · • Patients with severe hypoproteinaemia, e.g. in nephrotic syndrome.
Eintrag öffnenLeflunomide medac · 4.3 · • Patients with severe immunodeficiency states, e.g. AIDS.
Eintrag öffnenLeflunomide medac · 4.3 · • Pregnant women, or women of childbearing potential who are not using reliable contraception during treatment
Eintrag öffnenLeflunomide medac · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenLeflunomide medac · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenLeflunomide medac · 4.5 · 8 Effect of leflunomide on other medicinal products
Eintrag öffnenLeflunomide medac · 4.5 · 9 with warfarin alone. Therefore, when warfarin is co-administered, close INR follow-up and monitoring is reco
Eintrag öffnenLeflunomide medac · 4.5 · CYP450 inhibitors and inducers In vitro inhibition studies in human liver microsomes suggest that cytochrome P
Eintrag öffnenLeflunomide medac · 4.5 · Cholestyramine or activated charcoal It is recommended that patients receiving leflunomide are not treated wit
Eintrag öffnenLeflunomide medac · 4.5 · Effect of other medicinal products on leflunomide
Eintrag öffnenLeflunomide medac · 4.5 · Effect on BCRP (Breast Cancer Resistance Protein) and/or organic anion transporting polypeptide B1 and B3 (OAT
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