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Litfulo
Eintrag öffnenLitfulo · 4.1 Therapeutic indications · 1
Eintrag öffnenLitfulo · 4.3 Contraindications · 1
Eintrag öffnenLitfulo · 4.3 · • Hypersensitivity to the active substance(s) or to any of the excipients listed in section 6.1. • Active seri
Eintrag öffnenLitfulo · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenLitfulo · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenLitfulo · 4.5 · 6 The coadministration of multiple 600 mg doses of rifampicin, a strong inducer of CYP enzymes, decreased the
Eintrag öffnenLitfulo · 4.5 · Interaction studies have only been performed in adults.
Eintrag öffnenLitfulo · 4.5 · Multiple doses of 200 mg once daily ritlecitinib increased the AUCinf and Cmax of caffeine, a CYP1A2 substrate
Eintrag öffnenLitfulo · 4.5 · Multiple doses of 200 mg once daily ritlecitinib increased the AUCinf and Cmax of midazolam a CYP3A4 substrate
Eintrag öffnenLitfulo · 4.5 · Paediatric population
Eintrag öffnenLitfulo · 4.5 · Potential for other medicinal products to affect the pharmacokinetics of ritlecitinib
Eintrag öffnenLitfulo · 4.5 · Potential for ritlecitinib to affect the pharmacokinetics of other medicinal products
Eintrag öffnenLitfulo · 4.5 · Ritlecitinib did not produce clinically significant changes in the exposures of oral contraceptives (e.g., eth
Eintrag öffnenLitfulo · 4.5 · The coadministration of a single 400 mg dose of ritlecitinib increased the AUCinf of sumatriptan (an organic c
Eintrag öffnenLitfulo · 4.5 · The coadministration of multiple 200 mg doses of itraconazole, a strong CYP3A inhibitor, increased the area un
Eintrag öffnenLitfulo · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenLitfulo · 4.8 Undesirable effects · 1
Eintrag öffnenLitfulo · 4.8 · 8 Among all patients treated with ritlecitinib in the integrated safety analysis, including the long-term stud
Eintrag öffnenLitfulo · 4.8 · 9 elevations >5x ULN were reported in 6.6% of patients treated with ritlecitinib 50 mg or higher. Most elevati
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