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Lojuxta
Eintrag öffnenLojuxta · 4.1 Therapeutic indications · 1
Eintrag öffnenLojuxta · 4.3 Contraindications · 1
Eintrag öffnenLojuxta · 4.3 · 5 • Concomitant use of Lojuxta with strong or moderate CYP3A4 inhibitors (e.g. antifungal azoles such as itrac
Eintrag öffnenLojuxta · 4.3 · • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. • Patients with
Eintrag öffnenLojuxta · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenLojuxta · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenLojuxta · 4.5 · 10 Medicinal Effects on lomitapide levels Recommendation concerning products co-administration with lomitapide
Eintrag öffnenLojuxta · 4.5 · 11 Medicinal Effects on lomitapide levels Recommendation concerning products co-administration with lomitapide
Eintrag öffnenLojuxta · 4.5 · Coumarin anticoagulants When lomitapide 60 mg was administered to steady state and 6 days following warfarin 1
Eintrag öffnenLojuxta · 4.5 · Effects of lomitapide on other medicinal products
Eintrag öffnenLojuxta · 4.5 · Effects of other medicinal products on lomitapide and other forms of interaction
Eintrag öffnenLojuxta · 4.5 · Exercise additional caution if administering more than 1 weak CYP3A4 inhibitor with Lojuxta.
Eintrag öffnenLojuxta · 4.5 · Fenofibrate, niacin and ezetimibe When lomitapide was administered to steady state prior to micronised fenofib
Eintrag öffnenLojuxta · 4.5 · HMG-CoA reductase inhibitors (“statins”) Lomitapide increases plasma concentrations of statins. When lomitapid
Eintrag öffnenLojuxta · 4.5 · In vitro assessment of drug interactions Lomitapide inhibits CYP3A4. Lomitapide does not induce CYPs 1A2, 3A4,
Eintrag öffnenLojuxta · 4.5 · Inducers of Medicines that induce CYP3A4 When co-administering CYP3A4 inducers CYP3A4 would be expected to inc
Eintrag öffnenLojuxta · 4.5 · Oral contraceptives When lomitapide 50 mg was administered to steady state along with an oestrogen-based oral
Eintrag öffnenLojuxta · 4.5 · P-glycoprotein (P-gp) substrates Lomitapide inhibits P-gp in vitro, and may increase the absorption of P-gp su
Eintrag öffnenLojuxta · 4.5 · Table 3: Interactions between lomitapide and other medicinal products and other forms of interaction Medicinal
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