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Lynkuet
Eintrag öffnenLynkuet · 4.1 Therapeutic indications · 1
Eintrag öffnenLynkuet · 4.3 Contraindications · 1
Eintrag öffnenLynkuet · 4.3 · - Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. - Known or suspe
Eintrag öffnenLynkuet · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenLynkuet · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenLynkuet · 4.5 · CYP3A4 inhibitors (substances increasing exposure to elinzanetant) Co-administration of multiple daily doses o
Eintrag öffnenLynkuet · 4.5 · Effects of elinzanetant on other medicinal products
Eintrag öffnenLynkuet · 4.5 · Effects of other medicinal products on elinzanetant
Eintrag öffnenLynkuet · 4.5 · Elinzanetant is a weak inhibitor of CYP3A4. Co-administration of midazolam, a sensitive substrate of CYP3A4, a
Eintrag öffnenLynkuet · 4.5 · Elinzanetant is metabolised via CYP3A4 and is a substrate for the P-glycoprotein (P-gp) transporter protein.
Eintrag öffnenLynkuet · 4.5 · Elinzanetant should not be used together with strong CYP3A4 inhibitors (e.g. itraconazole, clarithromycin, rit
Eintrag öffnenLynkuet · 4.5 · If used concomitantly with moderate CYP3A4 inhibitors (e.g. erythromycin, ciprofloxacin, fluconazole, verapami
Eintrag öffnenLynkuet · 4.5 · No dose adjustment is required for weak CYP3A4 inhibitors.
Eintrag öffnenLynkuet · 4.5 · The concomitant use of elinzanetant with grapefruit (juice) is not recommended.
Eintrag öffnenLynkuet · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenLynkuet · 4.8 Undesirable effects · 1
Eintrag öffnenLynkuet · 4.8 · 5 Table 1: Adverse reactions System organ class Frequency VMS associated with VMS caused by AET menopause Psyc
Eintrag öffnenLynkuet · 4.8 · ALT and AST increased In the pooled safety data up to 52 weeks, the term ALT increased was reported in 0.6% of
Eintrag öffnenLynkuet · 4.8 · Description of selected adverse reactions
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