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Lynparza
Eintrag öffnenLynparza · 4.1 Therapeutic indications · 1
Eintrag öffnenLynparza · 4.3 Contraindications · 1
Eintrag öffnenLynparza · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Breast-feeding dur
Eintrag öffnenLynparza · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenLynparza · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenLynparza · 4.5 · A clinical study to evaluate the impact of itraconazole, a known CYP3A inhibitor, has shown that co-administra
Eintrag öffnenLynparza · 4.5 · A clinical study to evaluate the impact of rifampicin, a known CYP3A inducer, has shown that co-administration
Eintrag öffnenLynparza · 4.5 · Combination of olaparib with vaccines or immunosuppressant agents has not been studied. Therefore, caution sho
Eintrag öffnenLynparza · 4.5 · Combination with anastrozole, letrozole and tamoxifen A clinical study has been performed to assess the combin
Eintrag öffnenLynparza · 4.5 · Effect of olaparib on other medicinal products Olaparib inhibits CYP3A4 in vitro and is predicted to be a mild
Eintrag öffnenLynparza · 4.5 · In vitro, olaparib has been shown to be an inhibitor of BCRP, OATP1B1, OCT1, OCT2, OAT3, MATE1 and MATE2K. It
Eintrag öffnenLynparza · 4.5 · In vitro, olaparib inhibits the efflux transporter P-gp (IC50=76 µM), therefore it cannot be excluded that ola
Eintrag öffnenLynparza · 4.5 · Induction of CYP1A2, 2B6 and 3A4 has been shown in vitro with CYP2B6 being most likely to be induced to a clin
Eintrag öffnenLynparza · 4.5 · Pharmacodynamic interactions Clinical studies of olaparib in combination with other anticancer medicinal produ
Eintrag öffnenLynparza · 4.5 · Pharmacokinetic interactions Effect of other medicinal products on olaparib CYP3A4/5 are the isozymes predomin
Eintrag öffnenLynparza · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenLynparza · 4.8 Undesirable effects · 1
Eintrag öffnenLynparza · 4.8 · 11 Adverse reactions that most commonly led to dose interruptions and/ or reductions in monotherapy were anaem
Eintrag öffnenLynparza · 4.8 · 12 Table 1 Tabulated list of adverse reactions Adverse reactions MedDRA Frequency of All CTCAE grades Frequenc
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