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Lysodren
Eintrag öffnenLysodren · 4.1 Therapeutic indications · 1
Eintrag öffnenLysodren · 4.3 Contraindications · 1
Eintrag öffnenLysodren · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Lactation (see sec
Eintrag öffnenLysodren · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenLysodren · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenLysodren · 4.5 · 5 Enzyme induction is likely to persist after discontinuation of mitotane treatment.
Eintrag öffnenLysodren · 4.5 · Fat-rich food: Data with various mitotane formulations suggest that administration with fat-rich food enhances
Eintrag öffnenLysodren · 4.5 · Hormone binding protein: Mitotane has been shown to increase plasma levels of hormone binding proteins (e.g. s
Eintrag öffnenLysodren · 4.5 · Medicinal products active on central nervous system: Mitotane can cause central nervous system undesirable eff
Eintrag öffnenLysodren · 4.5 · Spironolactone: Mitotane must not be given in combination with spironolactone, since this active substance may
Eintrag öffnenLysodren · 4.5 · Substances metabolised through cytochrome P450: Mitotane has been shown to have an inductive effect on cytochr
Eintrag öffnenLysodren · 4.5 · Warfarin and coumarin-like anticoagulants: Mitotane has been reported to accelerate the metabolism of warfarin
Eintrag öffnenLysodren · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenLysodren · 4.8 Undesirable effects · 1
Eintrag öffnenLysodren · 4.8 · 6 Table 1: Frequency of adverse reactions Adverse reaction
Eintrag öffnenLysodren · 4.8 · 7 increased Blood testosterone decreased (in females) Sex hormone binding globulin increased Blood testosteron
Eintrag öffnenLysodren · 4.8 · 8 Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the me
Eintrag öffnenLysodren · 4.8 · Description of selected adverse reactions
Eintrag öffnenLysodren · 4.8 · Gastrointestinal disorders are the most frequently reported (10 to 100 % of patients) and are reversible when
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