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Eintrag öffnenMayzent · 4.1 Therapeutic indications · 1
Eintrag öffnenMayzent · 4.3 Contraindications · 1
Eintrag öffnenMayzent · 4.3 · - Hypersensitivity to the active substance, or to peanut, soya or any of the excipients listed in section 6.1.
Eintrag öffnenMayzent · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenMayzent · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenMayzent · 4.5 · 10 Anti-arrhythmic medicinal products, QT-prolonging medicinal products, medicinal products that may decrease
Eintrag öffnenMayzent · 4.5 · 11 The co-administration of fluconazole (moderate CYP2C9/CYP3A4 dual inhibitor) 200 mg daily at steady state a
Eintrag öffnenMayzent · 4.5 · Antineoplastic, immune-modulating or immunosuppressive therapies
Eintrag öffnenMayzent · 4.5 · Beta blockers
Eintrag öffnenMayzent · 4.5 · CYP2C9 and CYP3A4 inducers Siponimod may be combined with most types of CYP2C9 and CYP3A4 inducers. However, b
Eintrag öffnenMayzent · 4.5 · CYP2C9 inhibitors Concomitant use of siponimod and medicinal products that cause moderate or strong CYP2C9 inh
Eintrag öffnenMayzent · 4.5 · Caution should be exercised when siponimod is initiated in patients receiving beta blockers due to the additiv
Eintrag öffnenMayzent · 4.5 · Co-administration with siponimod did not reveal clinically relevant effects on the pharmacokinetics and pharma
Eintrag öffnenMayzent · 4.5 · Cytochrome P450 (CYP2C9) is the major metabolising enzyme for siponimod, accounting for 79.5% of metabolism in
Eintrag öffnenMayzent · 4.5 · Due to the characteristics and duration of alemtuzumab immune suppressive effects described in its product inf
Eintrag öffnenMayzent · 4.5 · During and for up to 4 weeks after treatment with siponimod vaccinations may be less effective. The efficacy o
Eintrag öffnenMayzent · 4.5 · During treatment initiation siponimod should not be concomitantly used in patients receiving class Ia (e.g. qu
Eintrag öffnenMayzent · 4.5 · No interaction studies have been performed with oral contraceptives containing other progestagens, however an
Eintrag öffnenMayzent · 4.5 · Oral contraceptives
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