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Mektovi
Eintrag öffnenMektovi · 4.1 Therapeutic indications · 1
Eintrag öffnenMektovi · 4.3 Contraindications · 1
Eintrag öffnenMektovi · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenMektovi · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenMektovi · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenMektovi · 4.5 · Binimetinib is a potential inducer of CYP1A2, and caution should be taken when it is used with sensitive subst
Eintrag öffnenMektovi · 4.5 · Binimetinib is a weak inhibitor of OAT3, and caution should be taken when it is used with sensitive substrates
Eintrag öffnenMektovi · 4.5 · Binimetinib is primarily metabolised through UGT1A1 mediated glucuronidation. The extent of drug interactions
Eintrag öffnenMektovi · 4.5 · Effects of binimetinib on other medicinal products
Eintrag öffnenMektovi · 4.5 · Effects of other medicinal products on binimetinib
Eintrag öffnenMektovi · 4.5 · Inducers of CYP1A2 enzymes (such as carbamazepine and rifampicin) and inducers of Pgp transport (such as Saint
Eintrag öffnenMektovi · 4.5 · While encorafenib is a relatively potent reversible inhibitor of UGT1A1, no differences in binimetinib exposur
Eintrag öffnenMektovi · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenMektovi · 4.8 Undesirable effects · 1
Eintrag öffnenMektovi · 4.8 · 11 Dysgeusia Common Facial paresisc Uncommon Visual impairment* Very common Eye disorders RPED* Very common Uv
Eintrag öffnenMektovi · 4.8 · 12 e includes haemorrhage at various sites including, but not limited to, cerebral haemorrhage, intracranial h
Eintrag öffnenMektovi · 4.8 · 13 occurred in one patient. Cerebral haemorrhage/intracranial haemorrhage occurred in 1.6% (6/372) of patients
Eintrag öffnenMektovi · 4.8 · 14 Rhabdomyolysis was reported in 0.3% (1/372) of patients treated with encorafenib in combination with binime
Eintrag öffnenMektovi · 4.8 · 15 Special populations
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