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Eintrag öffnenModigraf · 4.1 Therapeutic indications · 1
Eintrag öffnenModigraf · 4.3 Contraindications · 1
Eintrag öffnenModigraf · 4.3 · Hypersensitivity to tacrolimus or to any of the excipients listed in section 6.1. Hypersensitivity to other ma
Eintrag öffnenModigraf · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenModigraf · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenModigraf · 4.5 · 10 Medicinal products which have effects on tacrolimus Drug/Substance Class or Drug interaction effect Recomme
Eintrag öffnenModigraf · 4.5 · 11 Drug/Substance Class or Drug interaction effect Recommendations concerning co- Name administration The effe
Eintrag öffnenModigraf · 4.5 · 12 Drug/Substance Class or Drug interaction effect Recommendations concerning co- Name administration dose may
Eintrag öffnenModigraf · 4.5 · 13 Drug/Substance Class or Drug interaction effect Recommendations concerning co- Name administration Direct-a
Eintrag öffnenModigraf · 4.5 · As tacrolimus treatment may be associated with hyperkalaemia, or may increase pre-existing hyperkalaemia, high
Eintrag öffnenModigraf · 4.5 · Concomitant administration of tacrolimus with a mammalian target of rapamycin (mTOR) inhibitor (e.g., sirolimu
Eintrag öffnenModigraf · 4.5 · Effect of tacrolimus on the metabolism of other medicinal products Tacrolimus is a known CYP3A4 inhibitor; thu
Eintrag öffnenModigraf · 4.5 · Immunosuppressants may affect the response to vaccination and vaccination during treatment with tacrolimus may
Eintrag öffnenModigraf · 4.5 · It is recommended strongly to closely monitor tacrolimus blood levels under supervision of a transplant specia
Eintrag öffnenModigraf · 4.5 · Medicinal products which have effects on tacrolimus are listed in the table below. The examples of drug-drug i
Eintrag öffnenModigraf · 4.5 · Metabolic interactions Systemically available tacrolimus is metabolised by hepatic CYP3A4. There is also evide
Eintrag öffnenModigraf · 4.5 · Mycophenolic acid. Caution should be exercised when switching combination therapy from ciclosporin, which inte
Eintrag öffnenModigraf · 4.5 · Pharmacokinetics studies have indicated that the increase in tacrolimus blood levels when co- administered wit
Eintrag öffnenModigraf · 4.6 Fertility, pregnancy and lactation · 1
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