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Moventig
Eintrag öffnenMoventig · 4.1 Therapeutic indications · 1
Eintrag öffnenMoventig · 4.3 Contraindications · 1
Eintrag öffnenMoventig · 4.3 · 3 Strong CYP3A4 inhibitors Concomitant use with strong CYP3A4 inhibitors (e.g. clarithromycin, ketoconazole, i
Eintrag öffnenMoventig · 4.3 · Conditions in patients with cancer pain • Patients with underlying cancer who are at heightened risk of GI per
Eintrag öffnenMoventig · 4.3 · Gastrointestinal obstruction Patients with known or suspected gastrointestinal (GI) obstruction or in patients
Eintrag öffnenMoventig · 4.3 · Hypersensitivity Hypersensitivity to the active substance or to any of the excipients listed in section 6.1 or
Eintrag öffnenMoventig · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenMoventig · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenMoventig · 4.5 · 5 Grapefruit juice has been classified as a potent CYP3A4 inhibitor when consumed in large quantities. No data
Eintrag öffnenMoventig · 4.5 · As the effects of P-gp inhibitors on the PK of naloxegol were small relative to the effects CYP3A4 inhibitors,
Eintrag öffnenMoventig · 4.5 · Interaction with CYP3A4 inhibitors and inducers Interaction with strong CYP3A4 inhibitors In an open-label, no
Eintrag öffnenMoventig · 4.5 · Interaction with P-gp inhibitors A double-blind, randomized, 2-part, crossover, single centre study was conduc
Eintrag öffnenMoventig · 4.5 · Interaction with moderate CYP3A4 inhibitors In an open-label, non-randomized, fixed-sequence, 3-period, 3-trea
Eintrag öffnenMoventig · 4.5 · Interaction with other opioid antagonists Use of naloxegol with another opioid antagonist (e.g. naltrexone, na
Eintrag öffnenMoventig · 4.5 · Interaction with strong CYP3A4 inducers In an open-label, non-randomized, fixed-sequence, 3-period, 3-treatmen
Eintrag öffnenMoventig · 4.5 · No dosage adjustment is required for patients taking weak CYP3A4 inhibitors.
Eintrag öffnenMoventig · 4.5 · Paediatric population Interaction studies have only been performed in adults.
Eintrag öffnenMoventig · 4.5 · Therefore, a dose adjustment of naloxegol is recommended when co-administered with diltiazem and other moderat
Eintrag öffnenMoventig · 4.6 Fertility, pregnancy and lactation · 1
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