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Mysimba
Eintrag öffnenMysimba · 4.1 Therapeutic indications · 1
Eintrag öffnenMysimba · 4.3 Contraindications · 1
Eintrag öffnenMysimba · 4.3 · • Hypersensitivity to the active substance(s) or to any of the excipients listed in section 6.1. • Patients wi
Eintrag öffnenMysimba · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenMysimba · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenMysimba · 4.5 · Administration of naltrexone/bupropion to patients receiving either levodopa or amantadine concurrently should
Eintrag öffnenMysimba · 4.5 · Administration of naltrexone/bupropion with inhibitors or inducers of UGT 1A2 and 2B7 should be undertaken wit
Eintrag öffnenMysimba · 4.5 · Although clinical data do not identify a pharmacokinetic interaction between bupropion and alcohol, there have
Eintrag öffnenMysimba · 4.5 · Bupropion and its metabolites competitively inhibit the OCT2 in the basolateral membrane of the renal tubule r
Eintrag öffnenMysimba · 4.5 · Bupropion is metabolised to its major active metabolite hydroxybupropion primarily by the cytochrome P450 CYP2
Eintrag öffnenMysimba · 4.5 · CYP2B6 inducers, inhibitors and substrates Bupropion is metabolised to its major active metabolite hydroxybupr
Eintrag öffnenMysimba · 4.5 · CYP2D6 substrates In a clinical study, naltrexone/bupropion (32 mg naltrexone hydrochloride /360 mg bupropion
Eintrag öffnenMysimba · 4.5 · Caution should be used when prescribing naltrexone/bupropion to patients with predisposing factors that may in
Eintrag öffnenMysimba · 4.5 · Co-administration of bupropion with drugs that are metabolised by CYP2D6 isozyme including certain antidepress
Eintrag öffnenMysimba · 4.5 · Co-administration of medicinal products that may inhibit the metabolism of bupropion via CYP2B6 isoenzyme (e.g
Eintrag öffnenMysimba · 4.5 · Coadministration of naltrexone/bupropion with digoxin may decrease plasma digoxin levels. Monitor plasma digox
Eintrag öffnenMysimba · 4.5 · Drugs metabolised by cytochrome P450 (CYP) enzymes
Eintrag öffnenMysimba · 4.5 · Drugs which require metabolic activation by CYP2D6 in order to be effective (e.g., tamoxifen), may have reduce
Eintrag öffnenMysimba · 4.5 · Monoamine oxidase inhibitors (MAOI)
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