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Nilemdo
Eintrag öffnenNilemdo · 4.1 Therapeutic indications · 1
Eintrag öffnenNilemdo · 4.3 Contraindications · 1
Eintrag öffnenNilemdo · 4.3 · • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. • Pregnancy (see
Eintrag öffnenNilemdo · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenNilemdo · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenNilemdo · 4.5 · 5 If clinically relevant increased triglycerides or decreased HDL-C levels are detected, bempedoic acid or fib
Eintrag öffnenNilemdo · 4.5 · Bempedoic acid inhibits OAT2 in vitro, which may be the mechanism responsible for minor elevations in serum cr
Eintrag öffnenNilemdo · 4.5 · Effects of bempedoic acid on other medicinal products
Eintrag öffnenNilemdo · 4.5 · Effects of other medicinal products on bempedoic acid
Eintrag öffnenNilemdo · 4.5 · Ezetimibe Total ezetimibe (ezetimibe and its glucuronide form) and ezetimibe glucuronide AUC and maximum serum
Eintrag öffnenNilemdo · 4.5 · Fibrates Concomitant administration of fibrates with bempedoic acid resulted in increased triglycerides and de
Eintrag öffnenNilemdo · 4.5 · Increases in the incidences of anaemia and hyperuricaemia have been observed in patients with the concomitant
Eintrag öffnenNilemdo · 4.5 · Other interactions studied Bempedoic acid had no effect on the pharmacokinetics or pharmacodynamics of metform
Eintrag öffnenNilemdo · 4.5 · Probenecid Probenecid, an inhibitor of glucuronide conjugation, was studied to evaluate the potential effect o
Eintrag öffnenNilemdo · 4.5 · Statins The pharmacokinetic interactions between bempedoic acid 180 mg and simvastatin 40 mg, atorvastatin 80
Eintrag öffnenNilemdo · 4.5 · Transporter-mediated drug interactions Bempedoic acid and its glucuronide weakly inhibit OATP1B1 and OATP1B3 a
Eintrag öffnenNilemdo · 4.5 · Transporter-mediated drug interactions In vitro drug interaction studies suggest bempedoic acid, as well as it
Eintrag öffnenNilemdo · 4.5 · Triglycerides and HDL-C levels should be monitored at four weeks and periodically thereafter when bempedoic ac
Eintrag öffnenNilemdo · 4.6 Fertility, pregnancy and lactation · 1
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