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Eintrag öffnenNinlaro · 4.1 Therapeutic indications · 1
Eintrag öffnenNinlaro · 4.3 Contraindications · 1
Eintrag öffnenNinlaro · 4.3 · As ixazomib is administered in combination with lenalidomide and dexamethasone, refer to the SmPC for these me
Eintrag öffnenNinlaro · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenNinlaro · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenNinlaro · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenNinlaro · 4.5 · 7 4% and AUC was increased by 11%. Therefore, no dose modification is required for ixazomib with co-administra
Eintrag öffnenNinlaro · 4.5 · CYP inducers
Eintrag öffnenNinlaro · 4.5 · CYP inhibitors
Eintrag öffnenNinlaro · 4.5 · Co-administration of ixazomib with clarithromycin, a strong CYP3A inhibitor, did not result in a clinically me
Eintrag öffnenNinlaro · 4.5 · Co-administration of ixazomib with rifampicin decreased ixazomib Cmax by 54% and AUC by 74%. Therefore, co-adm
Eintrag öffnenNinlaro · 4.5 · Co-administration of ixazomib with strong CYP1A2 inhibitors did not result in a clinically meaningful change i
Eintrag öffnenNinlaro · 4.5 · Effect of ixazomib on other medicinal products
Eintrag öffnenNinlaro · 4.5 · Ixazomib is a low affinity substrate of P-gp. Ixazomib is not a substrate of BCRP, MRP2 or hepatic OATPs. Ixaz
Eintrag öffnenNinlaro · 4.5 · Ixazomib is not a reversible or a time-dependent inhibitor of CYPs 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, or 3A4/5. Ix
Eintrag öffnenNinlaro · 4.5 · Oral contraceptives
Eintrag öffnenNinlaro · 4.5 · Pharmacokinetic interactions
Eintrag öffnenNinlaro · 4.5 · Transporter-based interactions
Eintrag öffnenNinlaro · 4.5 · When ixazomib is administered together with dexamethasone, which is known to be a weak to moderate inducer of
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