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Nordimet
Eintrag öffnenNordimet · 4.1 Therapeutic indications · 1
Eintrag öffnenNordimet · 4.3 Contraindications · 1
Eintrag öffnenNordimet · 4.3 · - Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. - Severe hepatic
Eintrag öffnenNordimet · 4.3 · 5 - Pregnancy and breast-feeding (see section 4.6). - Concurrent vaccination with live vaccines.
Eintrag öffnenNordimet · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenNordimet · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenNordimet · 4.5 · 10 Cyclosporine may potentiate methotrexate efficacy and toxicity. There is an increased risk of renal dysfunc
Eintrag öffnenNordimet · 4.5 · 9 Therefore, coadministration should be avoided.
Eintrag öffnenNordimet · 4.5 · Alterations in bioavailability of methotrexate Salicylates, phenylbutazone, phenytoin, barbiturates, tranquill
Eintrag öffnenNordimet · 4.5 · Antibiotics, like penicillin, glycopeptides, sulfonamides, ciprofloxacin and cefalotin can, in individual case
Eintrag öffnenNordimet · 4.5 · Co-administration of proton-pump inhibitors such as omeprazole or pantoprazole can lead to interactions: conco
Eintrag öffnenNordimet · 4.5 · Colestyramine can increase the non-renal elimination of methotrexate by interrupting the enterohepatic circula
Eintrag öffnenNordimet · 4.5 · Cyclosporine
Eintrag öffnenNordimet · 4.5 · Folate metabolism Co-administration of medicinal products which cause folate deficiency (e.g. sulphonamides, t
Eintrag öffnenNordimet · 4.5 · Haematotoxic medicinal products Administration of additional haematotoxic medicinal products increases the lik
Eintrag öffnenNordimet · 4.5 · Hepatotoxicity Regular alcohol consumption and administration of additional hepatotoxic medicinal products inc
Eintrag öffnenNordimet · 4.5 · Immune-modulating medicinal products Particularly in the case of orthopaedic surgery where susceptibility to i
Eintrag öffnenNordimet · 4.5 · Leflunomide The combined use of methotrexate and leflunomide may increase the risk for pancytopenia. Methotrex
Eintrag öffnenNordimet · 4.5 · NSAIDs including salicylic acid In animal experiments NSAIDs including salicylic acid caused reduction of tubu
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