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Onpattro
Eintrag öffnenOnpattro · 4.1 Therapeutic indications · 1
Eintrag öffnenOnpattro · 4.3 Contraindications · 1
Eintrag öffnenOnpattro · 4.3 · Severe hypersensitivity (e.g., anaphylaxis) to the active substance or any of the excipients listed in section
Eintrag öffnenOnpattro · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenOnpattro · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenOnpattro · 4.5 · No formal clinical drug interaction studies have been performed. At doses higher than the clinically relevant
Eintrag öffnenOnpattro · 4.5 · Serum TTR is a carrier of retinol binding protein, which facilitates transport of vitamin A in the blood. Trea
Eintrag öffnenOnpattro · 4.5 · Vitamin A testing
Eintrag öffnenOnpattro · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenOnpattro · 4.8 Undesirable effects · 1
Eintrag öffnenOnpattro · 4.8 · 6 Table 1: Adverse reactions reported for Onpattro 300 micrograms per kg System Organ Class Adverse Reaction F
Eintrag öffnenOnpattro · 4.8 · 7 Extravasation
Eintrag öffnenOnpattro · 4.8 · Anti-drug antibodies to Onpattro were evaluated by measuring antibodies specific to PEG2000-C-DMG, a lipid com
Eintrag öffnenOnpattro · 4.8 · Description of selected adverse reactions
Eintrag öffnenOnpattro · 4.8 · Extravasation was observed in < 0.5% of infusions in clinical studies. Signs and symptoms included phlebitis o
Eintrag öffnenOnpattro · 4.8 · Immunogenicity
Eintrag öffnenOnpattro · 4.8 · In an open-label study in 23 hATTR amyloidosis patients with polyneuropathy progression post liver transplant,
Eintrag öffnenOnpattro · 4.8 · In clinical studies, all patients received premedication with a corticosteroid, paracetamol, and H1 and H2 blo
Eintrag öffnenOnpattro · 4.8 · In the placebo-controlled study, peripheral oedema was reported in 29.7% of Onpattro-treated patients and 22.1
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