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Eintrag öffnenOtezla · 4.1 Therapeutic indications · 1
Eintrag öffnenOtezla · 4.3 Contraindications · 1
Eintrag öffnenOtezla · 4.3 · Hypersensitivity to the active substance(s) or to any of the excipients listed in section 6.1.
Eintrag öffnenOtezla · 4.3 · Pregnancy (see section 4.6).
Eintrag öffnenOtezla · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenOtezla · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenOtezla · 4.5 · Co-administration of strong cytochrome P450 3A4 (CYP3A4) enzyme inducer, rifampicin, resulted in a reduction o
Eintrag öffnenOtezla · 4.5 · In clinical studies, apremilast has been administered concomitantly with topical therapy (including corticoste
Eintrag öffnenOtezla · 4.5 · There was no clinically meaningful interaction between ketoconazole and apremilast. Apremilast can be co-admin
Eintrag öffnenOtezla · 4.5 · There was no pharmacokinetic interaction between apremilast and methotrexate in psoriatic arthritis patients.
Eintrag öffnenOtezla · 4.5 · There was no pharmacokinetic interaction between apremilast and oral contraceptives containing ethinyl estradi
Eintrag öffnenOtezla · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenOtezla · 4.8 Undesirable effects · 1
Eintrag öffnenOtezla · 4.8 · 7 System Organ Class Frequency Adverse reaction
Eintrag öffnenOtezla · 4.8 · 8 from weight loss. None of the patients discontinued the study due to adverse reaction of weight decreased.
Eintrag öffnenOtezla · 4.8 · Body weight loss Patient weight was measured routinely in clinical studies. The mean observed weight loss in a
Eintrag öffnenOtezla · 4.8 · Description of selected adverse reactions
Eintrag öffnenOtezla · 4.8 · Elderly patients From post-marketing experience, elderly patients ≥ 65 years of age may be at a higher risk of
Eintrag öffnenOtezla · 4.8 · Frequencies are defined as: very common (≥ 1/10); common (≥ 1/100 to < 1/10); uncommon (≥ 1/1 000 to < 1/100);
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